Clinical of Yinzhihuang Granules(茵栀黄颗粒)Combined with Clostridium Caseinate Live Powder in Treatment of Neonatal Pathological Jaundice
Objective To study the clinical effect and safety of Yinzhihuang Granules(茵栀黄颗粒)combined with Clostridi-um Caseinate Live Powder in the treatment of neonatal pathological jaundice.Methods A total of 142 cases of neonatal pathologi-cal jaundice(admitted from February 2021 to February 2023)were included in this study.The children were divided into obser-vation group and control group by random number table method,with 71 cases in each group.All the enrolled children were trea-ted with blue light irradiation,while the control group were treated with Live Clostridium Caseinate Powder.The observation group combined with Yinzhihuang Granules on the basis of the control group.The treatment effect,serum bilirubin level changes before and after treatment and traditional Chinese medicine syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)changes,jaundice regression time and hospital stay,immune function index changes and adverse reactions of two groups were compared.Results The total effective rates of observation group and control group were 97.18％vs 88.73％(P＜0.05).Before treatment,the levels of total bilirubin(TBil),indirect bilirubin(IBil),bound bilirubin(DBil),total bilirubin(TBIL)and indirect bilirubin(IBIL)and other bilirubin indexes were detected in two groups.TCM syn-drome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.),CD4+T lymphocytes,CD8+T lymphocytes and CD4+/CD8+were not significant(P＞0.05).After treatment,the levels of TBil,IBil and DBil,TCM syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)were all decreased in two groups,and the values of CD4+and CD4+/CD8+were all increased.After treatment,the levels of TBil,IBil and DBil,TCM syndrome scores(yellow complexion and skin,reluctance to suckle,dry lips,deep yellow urine,white stool like clay,etc.)in the observation group were lower than those in the control group,and the values of CD4+and CD4+/CD8+were higher than those in the control group(P＜0.05).Compared with that of fhe control group,the duration of jaundice resolution and hospitalization was shorter in the observation group(P＜0.05).The adverse reaction rate was lower in both groups(P＞0.05).Conclusion Yinzhihuang Granules combined with Clostridium Caseinate Live Powder in the treatment of neonatal pathological jaundice has significant clinical effect.The symptoms of the patients can be improved.The recovery is fast,the im-mune function of the patients can be improved,and the treatment safety is high,which is worthy of applying
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