Effect of Modified Qingwen Baidu Drink(清瘟败毒饮加减)on Clinical Improvement in Pediatric Kawasaki Disease(Dual Blaze of Qi and Blood Syndrome)and Its Effects on Serum Inflammation and Immune Function in Affected Children
Objective To observe the clinical efficacy of Modified Qingwen Baidu Drink(清瘟败毒饮加减)combined with immunoglobulin in the treatment of pediatric Kawasaki disease(dual blaze of Qi and blood syndrome)and its impact on serum in-flammation and immune function in children.Methods A total of 220 pediatric patients with Kawasaki disease who were treated in the cardiology department of the hospital from January 2020 to December 2023 were selected and randomly divided into two groups,with 110 cases in each group.The control group received aspirin combined with immunoglobulin treatment,while the ob-servation group received Modified Qingwen Baidu Drink in addition to the treatment of the control group.The clinical efficacy,symptom disappearance time,serum inflammatory cytokine levels,immune function and cardiac function changes between two groups of patients before and after treatment were compared.Results The effective rate of the control group was 90.91％(100/110),while that of the observation group was 98.18％(108/110).Compared with that of the control group,the effective rate of the observation group was significantly increased(P＜0.05).Compared with that of the control group,the disappearance time of typical clinical symptoms such as fever in the observation group was significantly shortened(P＜0.01).After intervention,in the observation group,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)were significantly reduced compared to those of the control group(P＜0.01).There was no significant difference in the levels of im-mune function indicators between the two groups before intervention(P＞0.05).After intervention,the levels of CD4+and CD4+/CD8+in the observation group were significantly increased compared to those of the control group,while the levels of CD8+were significantly decreased with statistical significance(P＜0.01,P＜0.05).The level of CD3+showed an upward trend,but the difference was not statistically significant(P＞0.05).There was no significant difference in heart function between the two groups before intervention(P＞0.05).After intervention,the serum levels of heart-type fatty acid binding protein(h-FAB)and B-type natriuretic peptide(BNP)in the observation group were significantly reduced compared to those of the control group(P＜0.01).The main adverse reactions of all patients during the intervention process were nausea,vomiting,loss of appetite,ab-dominal pain and diarrhea,with mild symptoms.There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combined treatment of Qingwen Baidu Drink with modifications and intravenous im-munoglobulin demonstrates considerable efficacy in treating Kawasaki disease in children.This approach notably improves clini-cal symptoms,suppresses inflammatory responses,protects cardiac function,modulates immune function and minimizes adverse re-actions.
Qingwen Baidu Yin(清瘟败毒饮)Kawasaki disease in childrendual blaze of Qi and blood syndromegamma globulinimmune functioninflammation levelclinical research
万方数据
维普
