Research Progress on Extraction,Isolation,Structural Characterization and Biological Activity of Polysaccharides from Baizhu(Atractylodis Macrocephalae Rhizoma)
As a traditional Chinese medicinal material for tonifying deficiency,Baizhu(Atractylodis Macrocephalae Rhizoma)is widely used in clinical practice.Modern studies have found that it mainly contains volatile oil,polysaccharide,lactones,amino acids and other chemical components,among which the polysaccharide content is high,and it has extensive drug development and research value.In recent years,a lot of researches have been carried out on the polysaccharide of Baizhu(Atractylodis Macro-cephalae Rhizoma),including its extraction,isolation,structure identification and pharmacological action.At present,the main methods for the determination of polysaccharide content of Baizhu(Atractylodis Macrocephalae Rhizoma)include anthrone-sul-furic acid method and phenol-sulfuric acid method,and the extraction methods of polysaccharide can be decocting method,ultra-sonic-assisted extraction,complex enzyme extraction,microwave-assisted extraction,etc.The main separation methods are col-umn chromatography,ethanol step precipitation,ultrafiltration and so on.It is found that different methods of extraction,separation and determination have great influence on polysaccharide content.In addition,the study of polysaccharide structure is still in the initial stage,only some of the refined polysaccharide structure has been analyzed,and most of the structure has not been clarified.At present,the biological activities of the polysaccharide mainly include anti-tumor activity,immunomodulatory activity,neuro-protective effect,gastrointestinal function regulation,liver protection effect and growth promotion effect.These studies only exist in simple pharmacodynamic evaluation,and the specific mechanism of action and the structure-activity relationship have not been widely carried out.In this study,the literature on extraction and separation methods,chemical structure and main biological activ-ities of polysaccharides from Baizhu(Atractylodis Macrocephalae Rhizoma)in recent 10 years was reviewed and summarized,so as to provide reference for further research,development and utilization of polysaccharides.
polysaccharide of Baizhu(Atractylodis Macrocephalae Rhizoma)extraction and separationpolysaccharide struc-turebiological activity
万方数据
维普
