The"tumor microenvironment"formed by the tissues,immune cells,blood vessels and extracellular matrix around the tumor promotes the proliferation and invasion of the tumor,thereby increasing the occurrence,development and death of canc-er.Current studies have shown that chronic psychological stress can affect the tumor microenvironment by regulating metabolism and immune function,thereby inducing tumor progression.Traditional Chinese medicine can cause internal organ disorders,a-mong which liver and spleen disorders are the core pathogenesis of tumor microenvironment formation.Based on the theory of"e-motional disease"in traditional Chinese medicine,this paper systematically discussed the scientific connotation of chronic psycho-logical stress-mediated tumor microenvironment from the"liver-spleen"metabolic immunity level,and deeply explored the na-ture of liver depression and spleen deficiency in the tumor microenvironment caused by emotional disorders,thereby revealing the law of occurrence and development of malignant tumors induced by chronic psychological stress mediated tumor microenviron-ment,and providing new ideas for further elaboration of the pathogenesis of chronic psychological stress mediated tumor microen-vironment to promote tumor pathogenesis and for the diagnosis and treatment of emotional carcinogenesis.
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