首页|基于"肝-脾"代谢免疫对话探究慢性心理应激调控肿瘤微环境的科学内涵

基于"肝-脾"代谢免疫对话探究慢性心理应激调控肿瘤微环境的科学内涵

扫码查看
原文链接
  • 万方数据
肿瘤周围的组织、免疫细胞、血管和细胞外基质共同形成的"肿瘤微环境"促进了肿瘤的增殖与侵略,从而增加了癌症的发生、发展与死亡.目前研究表明慢性心理应激可通过调控代谢和免疫功能影响肿瘤微环境,进而诱导肿瘤进程.中医情志致病可致脏腑失调,其中肝脾失调是肿瘤微环境形成的核心病机.基于中医"情志致病"理论,从"肝-脾"代谢免疫层面系统探讨了慢性心理应激介导肿瘤微环境的科学内涵,深入探索情志失调所致肿瘤微环境的肝郁和脾虚本质,从而揭示慢性心理应激介导肿瘤微环境诱导恶性肿瘤的发生发展规律,并为进一步阐述慢性心理应激介导肿瘤微环境促进肿瘤的发病机制以及为情志致癌的诊疗提供新思路.
Exploring Scientific Connotation of Chronic Psychological Stress Mediated Tumor Microenvironment from"Liver-Spleen"
The"tumor microenvironment"formed by the tissues,immune cells,blood vessels and extracellular matrix around the tumor promotes the proliferation and invasion of the tumor,thereby increasing the occurrence,development and death of canc-er.Current studies have shown that chronic psychological stress can affect the tumor microenvironment by regulating metabolism and immune function,thereby inducing tumor progression.Traditional Chinese medicine can cause internal organ disorders,a-mong which liver and spleen disorders are the core pathogenesis of tumor microenvironment formation.Based on the theory of"e-motional disease"in traditional Chinese medicine,this paper systematically discussed the scientific connotation of chronic psycho-logical stress-mediated tumor microenvironment from the"liver-spleen"metabolic immunity level,and deeply explored the na-ture of liver depression and spleen deficiency in the tumor microenvironment caused by emotional disorders,thereby revealing the law of occurrence and development of malignant tumors induced by chronic psychological stress mediated tumor microenviron-ment,and providing new ideas for further elaboration of the pathogenesis of chronic psychological stress mediated tumor microen-vironment to promote tumor pathogenesis and for the diagnosis and treatment of emotional carcinogenesis.

chronic psychological stresstumor microenvironmentemotional illnessliver depressionspleen deficiency

钟悦、王志宇、郑轶枫、王能

展开 >

广州中医药大学基础医学院,中西医结合基础研究中心,广东 广州 510006

省部共建中医湿证国家重点实验室,广州中医药大学第二附属医院,广东 广州 510120

粤港澳中医药与免疫疾病研究联合实验室,广州中医药大学第二附属医院,广东 广州 510120

广东省中医证候临床研究重点实验室,广东 广州 510120

展开 >

慢性心理应激 肿瘤微环境 情志致病 肝郁 脾虚

国家自然科学基金项目国家自然科学基金项目国家自然科学基金项目省部共建中医湿证国家重点实验室专项广东省科技计划项目广东省科技计划项目广东省科技计划项目广东省科技计划项目广东省科技创新战略专项资金(粤港澳联合实验室)项目广东省中医院院内专项广州中医药大学青年英才项目

819735268207416582374446SZ2021ZZ192023B12120600632022B15152300022021A05050300592017B0303141662020B1212030006YN2018MJ07QNYC20190101

2024

10.13193/j.issn.1673-7717.2024.10.022

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(10)
  • 13