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基于"痰湿不孕"探析多囊卵巢综合征的发病机制

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基于对古代中医"痰湿不孕"理论的阐释,探讨痰湿与多囊卵巢综合征(PCOS)的关系,从中西医角度,深入阐析多囊卵巢综合征的发病机制.认为"窠囊之痰"的产生是多囊卵巢形成的特征表现,痰湿阻塞胞宫是多囊卵巢综合征的发病关键.痰湿可引发卵巢多囊样的改变和下丘脑-垂体-卵巢轴(HPOA)的调控失常,造成机体激素代谢紊乱、糖脂异常,并且诱导氧化应激,同时激发铁死亡.上述机制相互作用,进而影响胞宫生殖功能,卵泡发育障碍,最终导致多囊卵巢综合征的发生.
Exploring Pathogenesis of Polycystic Ovary Syndrome Based on Phlegm-Dampness Infertility
Based on the theory of infertility caused by phlegm-dampness in ancient traditional Chinese medicine,the rela-tionship between phlegm-dampness and polycystic ovary syndrome was discussed,and the pathogenesis of polycystic ovary syn-drome was elaborated from the perspective of traditional Chinese and western medicine.It is believed that the production of"phlegm of the cyst"is the characteristic manifestation of polycystic ovary formation,and the obstruction of the cell palace by phlegm and dampness is the key to the pathogenesis of polycystic ovary syndrome.Phlegm and dampness can cause polycystic changes of ovary and abnormal regulation of hypothalamic-pituitary-ovarian axis,resulting in hormone metabolism disorder,glu-colipid abnormality,oxidative stress and iron death.The above mechanisms interact with each other,and then affect the reproduc-tive function of the cytocytosis and the development of follicles,which eventually lead to the occurrence of polycystic ovary syn-drome.

polycystic ovary syndromephlegm-dampness infertilitypathogenesis

李佳、王亚男、吴兆利、丛培玮

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辽宁中医药大学研究生学院,辽宁沈阳 110847

辽宁中医药大学针灸推拿学院,辽宁沈阳 110847

辽宁中医药大学中医脏象理论及应用国家教育部重点实验室,辽宁沈阳 110847

多囊卵巢综合征 痰湿不孕 发病机制

国家自然科学基金青年科学基金项目中国博士后科学基金第71批面上资助"地区专项支持计划"项目辽宁省自然科学基金项目辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金项目

821047352022MD7137642019-ZD-0953zyzx2202

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(10)
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