首页|情志应激促进肿瘤转移机制的研究进展

情志应激促进肿瘤转移机制的研究进展

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情志应激与多种疾病的"易感性"相关,肿瘤的发展转移受情志因素的影响明显.在中医理论指导下,分析了情志应激诱导脏腑功能失调进而导致的气血紊乱状态对癌毒转移扩散的影响;介绍了常用的情志应激模型并讨论其优点和不足,以期更好地运用现代生物学技术来研究情志应激导致的机体病理变化.结合现代医学研究进展,综述了情志应激对肿瘤转移影响的现代生物学调控机制,涉及多靶点和复杂机制,其中神经内分泌系统与免疫系统发挥关键作用.持续激活的下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴和交感神经系统(sympathetic nervous sys-tem,SNS)导致糖皮质激素(glucocorticoids,GCs)和去甲肾上腺素(norepinephrine,NE)等激素的释放及其受体的激活,进而改变了肿瘤微环境,促进肿瘤细胞的增殖、迁移和侵袭;不仅如此,激活的神经内分泌系统产生的应激激素也能够通过作用免疫系统,影响免疫细胞数量和功能;同时,情志应激诱导的氧化应激状态和肠道菌群失调等,也能造成机体的免疫抑制和炎症反应,从而加剧肿瘤细胞的免疫逃逸和转移.旨在深入研究情志应激与肿瘤转移的关系,为发掘中医药治疗肿瘤靶点和策略提供参考.
Research Progress on Mechanisms of Psychological Stress Promoting Tumor Metastasis
Psychological stress has been associated with an increased"susceptibility"to various diseases and its impact on tumor development and metastasis is particularly pronounced.This article,guided by principles of traditional Chinese medicine,examines how dysfunction of visceral organs induced by psychological stress leads to disturbances in Qi and blood,subsequently influencing the spread and metastasis of malignant tumors.We also present commonly utilized models for studying psychological stress,discussing their respective advantages and limitations.The objective is to enhance the application of modern biological techniques in investigating stress-induced pathological changes within the body.Drawing from advancements in contemporary medical research,we provide a comprehensive review of the biological mechanisms through which psychological stress influences tumor metastasis,highlighting multiple targets and complex pathways involved.Notably,both the neuroendocrine system and im-mune system play critical roles in this process.Sustained activation of the hypothalamic-pituitary-adrenal(HPA)axis and the sympathetic nervous system(SNS)lead to the release of hormones such as glucocorticoids(GCs)and norepinephrine(NE),along with the activation of their receptors.Consequently,these events lead to alterations in the tumor microenvironment,promoting the proliferation,migration and invasion of tumor cells.Furthermore,stress hormones produced by the activated neuroendocrine sys-tem can impact the immune system,affecting the quantity and function of immune cells.Simultaneously,psychological stress-in-duced oxidative stress and dysbiosis in the gut microbiota can lead to immune suppression and inflammatory responses,exacerba-ting the immune escape and metastasis of tumor cells.The aim of this article is to delve into the relationship between psychologi-cal stress and tumor metastasis,providing reference for exploring tumor targets and strategies in traditional Chinese medicine treat-ment.

psychological stresschronic stresslipid peroxidationtumor metastasisreview

刘洋、吴燕萍、罗祥、梁磊、何蓉蓉

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广东省疾病易感性及中医药研发工程技术研究中心,广州市疾病易感性与中医药防治重点实验室,广东省粤港澳高校联合实验室,生物活性分子与成药性优化全国重点实验室,教育部中药与创新药物研究国际合作联合实验室,广东省中药药效物质基础及创新药物研究重点实验室,暨南大学,广东 广州 510632

暨南大学药学院,广东 广州 510632

暨南大学中医学院,广东 广州 510632

情志应激 慢性应激 脂质过氧化 肿瘤转移 综述

国家自然科学基金杰出青年科学基金项目国家自然科学基金面上项目国家自然科学基金面上项目国家自然科学基金青年科学基金项目国家自然科学基金青年科学基金项目中国博士后科学基金第4批特别资助(站前)项目广东省自然科学基金项目广东省基础与应用基础研究基金区域联合基金青年项目广东省粤港澳高校联合实验室项目

82125038819737188237432782004231823050632022TQ01222021A15150112972020A15151103882023LSYS002

2024

10.13193/j.issn.1673-7717.2024.10.031

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(10)
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