Efficacy and Mechanism of Yishen Zhuyu Decoction(益肾逐瘀汤)Combined with External Application of Traditional Chinese Medicine in Treatment of Benign Prostatic Hyperplasia with Overactive Bladder
Objective To study the efficacy and mechanism of Yishen Zhuyu Decoction(益肾逐瘀汤)combined with external application of traditional Chinese medicine in the treatment of benign prostatic hyperplasia with overactive bladder.Method-s Ninety patients with benign prostatic hyperplasia and bladder overactivity admitted to the Urology Department of The First Affili-ated Hospital of Guangxi University of Chinese Medicine from July 2022 to April 2023 were randomly divided into the convention-al drug group,the traditional Chinese medicine external application group and the Yishen Zhuyu Decoction group,with 30 cases in each group.The three groups were treated with conventional drug(tolterodine).The traditional Chinese medicine external appli-cation group was treated with traditional Chinese medicine on the basis of Tolterodine.The Yishen Zhuyu Decoction group was treated with traditional Chinese medicine external application combined with Yishen Zhuyu Decoction concentrated pill orally on the basis of tolterodine.After 2 weeks of treatment,the effective rate of treatment,maximum urinary flow rate(Qmax),urine vol-ume(VV),international prostate symptom score(IPSS),overactive bladder symptom score(OABSS),prostatic corpuscle leakage protein(PSEP),hemorheology[whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV)]and serum sex hormones[luteinizing hormone(LH),testosterone(T)]were compared among the three groups.Results The total effective rates of the conventional drug group,the traditional Chinese medicine external application group and the Yishen Zhuyu Decoction group were 73.33％(22/30),90.00％(27/30)and 96.67％(29/30),respectively.The rate of the Yishen Zhuyu Decoction group was significantly higher than that of the conventional drug group(P＜0.05).After treatment,the values of Qmax and VV of the three groups were significantly increased,and the value of the Yishen Zhuyu Decoction group was significantly higher than that of the conventional drug group and the traditional Chinese medicine external application group(P＜0.05).After treatment,the IPS and OABSS scores of the three groups were significantly decreased,and the score of the Yishen Zhuyu Decoction group was signif-icantly lower than that of the conventional drug group and the traditional Chinese medicine external application group(P＜0.05).After treatment,the levels of PSEP,HBV,LBV and LH in the three groups were significantly decreased,and the level of T was significantly increased.The levels of PSEP,HBV,LBV and LH in the Yishen Zhuyu Decoction group were significantly lower than those in the conventional drug group and the external application of traditional Chinese medicine group,and the level of T was significantly higher than that in the conventional drug group and the external application of traditional Chinese medicine group,with statistically significant differences(P＜0.05).Conclusion The effect of Yishen Zhuyu Decoction combined with ex-ternal application of traditional Chinese medicine in the treatment of benign prostatic hyperplasia with overactive bladder is satis-factory.It can improve the total effective rate and the hemorheology,and promote the balance of sex hormone levels and the reha-bilitation of patients.
prostatic hyperplasiaoveractive bladderYishen Zhuyu Decoction(益肾逐瘀汤)external application of tradi-tional Chinese medicinetolterodine
万方数据
维普
