History and Research Progress of Buguzhi(Psoraleae Fructus)Processing
Buguzhi(Psoraleae Fructus)is a traditional Chinese medicine which can warm kidney and assist Yang.There is a long history of its processing and a variety of processing methods and products.The processing method of Buguzhi(Psoraleae Fructus)was first published in Leigong Paozhi Lun,and the main chemical constituents were flavonoids,coumarins,monoterpene phenols,benzofurans and others,with anti-cancer,anti-inflammatory,anti-osteoporosis and hypoglycemic activities,as well as immune regulation,bacteriostasis and protection of cardiovascular and other effects.In recent years,the clinical use of Buguzhi(Psoraleae Fructus)and its preparations can cause patients with liver,kidney and reproductive toxicity and other side effects.The studies have shown that psoralen glycoside,psoralen phenol,psoralen and so on are the main material basis of Buguzhi(Psor-aleae Fructus)toxicity.Different processing methods can change the main chemical components and toxic and side effects of Bu-guzhi(Psoraleae Fructus).In this paper,the history of Buguzhi(Psoraleae Fructus)processing and the present research situation were reviewed,in order to lay a foundation for the processing mechanism,pharmacodynamics and toxicity of Buguzhi(Psoraleae Fructus)as well as the follow-up research.
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