Effects of Mahuang Fuzi Xixin Decoction(麻黄附子细辛汤)Combined with Montelukast Sodium on Symptom Improvement and Levels of Dendritic Cell mDCs and pDCs in Peripheral Blood in Children with Cough Variant Asthma
Objective To analyze the effect of Mahuang Fuzi Xixin Decoction(麻黄附子细辛汤)combined with montelukast sodium on symptom improvement,the levels of myeloid dendritic cells(mDCs)and plasmacytoid dendritic cells(pDCs)in pe-ripheral blood and lung function after treatment.Methods A total of 132 children with cough variant asthma who were admitted to the hospital from January 2019 to December 2020 were selected as the research objects.They were divided into two groups ac-cording to random number table method.The control group(66 cases)received montelusna on the basis of conventional atomiza-tion therapy.The observation group(66 cases)were treated with Mahuang Fuzi Xixin Decoction based on the control group.The changes of mDCs and pDCs in peripheral blood and the ratio of mDCs/pDCs,symptom improvement and lung function of the two groups were detected before and after treatment at 1,2,3 and 4 weeks.The recurrence was observed after one year follow-up.Results There was no change in the proportion of mDCs in peripheral blood of the two groups before and after treatment(P＞0.05).The proportion of pDCs in peripheral blood of both groups continued to decrease after treatment(P＜0.05),but the pro-portion of pDCs in peripheral blood of the observation group was lower than that of the control group at 2 and 3 weeks after treat-ment(P＜0.05).The ratio of mDCs/pDCs in the two groups increased after treatment(P＜0.05),but the ratio of mDCs/pDCs in the observation group was higher than that of the control group at 2 and 3 weeks after treatment(P＜0.05).After 4 weeks of treatment,the cough score of the observation group was lower than that of the control group(P＜0.05).After 4 weeks of treat-ment,the indexes of lung function in the observation group were better than those in the control group(P＜0.05).After one year of follow-up,all cases did not shed,and the recurrence rate of the observation group was 4.55％(3/66),lower than that of the control group[15.15％(10/66)](P＜0.05).Conclusion Mahuang Fuzi Xixin Decoction combined with montelukast sodium in the treatment of cough variant asthma can more rapidly reduce the proportion of peripheral blood pDCs and increase the ratio of mDCs/pDCs,which is helpful to quickly correct the imbalance of Th1/Th2 in children and relieve clinical symptoms and optimize the lung function,and the prognosis is better.
万方数据
维普
