Effect of Shengmai Qiangxin Granules(生脉强心颗粒)on Chronic Heart Failure in Senile Patients
Objective To investigate the curative effect of Shengmai Qiangxin Granules(生脉强心颗粒)in the treatment of chronic heart failure in the elderly and its influence on cardiac remodeling and myocardial injury markers.Methods A total of 86 elderly patients with chronic heart failure admitted to Heart disease Department of the hospital from June 2021 to December 2022 were included in the study and divided into observation group and control group with 43 cases in each group by random number table method.The control group received conventional anti-heart failure western drug and the observation group was additionally given Shengmai Qiangxin Granules orally,1 bag for each time,twice a day.After 30 days of continuous medication,the main in-dexes of the two groups were observed and compared,including TCM syndrome scores,clinical efficacy and reduction and with-drawal rate of western medicine.And the secondary indicators were observed and compared,including left ventricular diastolic/systolic function[early peak diastolic blood flow velocity(E)/late peak diastolic blood flow velocity(A),left ventricular short axis shortening rate(FS),ejection fraction(EF)],cardiac remodeling index[left atrial diameter(LAD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),ventricular septal thickness(IVST),left ventricular poste-rior wall thickness(LVPWT)],serum markers of myocardial injury[creatine kinase isoenzyme-MB(CK-MB),cardiac troponin T(cTnT)],inflammatory factors[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],quality of life(Minnesota Heart Failure Quality of Life Questionnaire score)and exercise tolerance(farthest walking distance in 6 mi-nutes).Results After treatment,the total effective rate(90.70％,39/43),diuretic reduction and discontinuing rate(88.37％,38/43)and digoxin reduction and discontinuing rate(90.70％,39/43)in the observation group were significantly higher than those in the control group[69.77％(30/43),69.77％(30/43)and 72.09％(31/43)],and there were significant differences a-mong groups(P＜0.05).After treatment,the scores of TCM symptoms and Minnesota Heart failure Quality of Life questionnaire were significantly decreased in the observation group compared with those of the control group(P＜0.05),while the farthest walk-ing distance in 6 min was significantly increased(P＜0.05).After treatment,the values of E/A,FS and EF in the observation group were significantly increased compared with those of the control group(P＜0.05),but the values of LAD,LVESD,LVEDD,IVST and LVPWT and the levels of CK-MB,cTnT,hs-CRP and TNF-α in the observation group were significantly decreased compared with those of the control group(P＜0.05).Conclusion Shengmai Qiangxin Granules used in the treatment of chronic heart failure in the elderly can effectively promote cardiac remodeling,improve the cardiac function and the curative effect,and significantly improve the quality of life and exercise tolerance of the patients.
Shengmai Qiangxin Granules(生脉强心颗粒)chronic heart failurecardiac remodelingmarkers of myocardial injurycurative effect
万方数据
维普
