Clinical Effect of Modified Zhibi Decoction(治痹汤加减)on Elderly KOA Patients
Objective To investigate the clinical effect of Modified Zhibi Decoction(治痹汤加减)in the treatment of elderly patients with knee osteoarthritis(KOA).Methods A hundred and fifty elderly patients with KOA who were treated in the hospital from January 2020 to January 2023 were selected and divided into observation group(79 cases)and control group(71 cases).The control group was given conventional treatment,and the observation group was treated with Modified Zhibi Decoction on the basis of the control group.The treatment effect and quality of life of the two groups were observed.The serum osteopontin(OPN),matrix metalloproteinase-3(MMP-3),glucose-6-phosphate isomerase(GPI)and anti mutant citrullinated vimen-tin(MCV)antibodies were detected before and after treatment.Results The curative effect of the observation group was better than that of the control group(P＜0.05),and the total effective rate was 96.20％(76/79).The visual analog scale(VAS)score and TCM symptom scores of the observation group after treatment were(1.20±0.32)points and(3.40±1.00)points,respec-tively,which were significantly lower than those of the control group(P＜0.05),while the Japanese Orthopedics Association(JO A)score was(84.40±10.21)points,which was significantly higher than that of the control group(P＜0.05).After treat-ment,the MOS item short from health survey(SF-36)scores of physiological function,role-physical,physical pain,general health and mental health of the observation group were(76.39±9.11)points,(80.02±8.81)points,(77.10±10.32)points,(75.50±9.92)points and(80.03±7.91)points,respectively,which were significantly higher than those of the control group(P＜0.05).After treatment,the levels of serum osteopontin(OPN),matrix metalloproteinase-3(MMP-3),glucose-6-phosphate isomerase(GPI)and anti mutant citrullinated vimentin(MCV)antibody in the observation group were(27.72±6.60)mg/L,(120.01±31.17)mg/L,(0.04±0.01)mg/L and(4.92±1.02)U/mL,respectively,which were significantly lower than those in the control group(P＜0.05).The incidence of adverse reactions between the observation group and the control group was not statistically significant(P＞0.05).Conclusion Modified Zhibi Decoction has better clinical effect in the treatment of eld-erly patients with KOA,improve the survival treatment and significantly reduce the levels of serum OPN,MMP-3,GPI and anti MCV antibody.
Zhibi Decoction(治痹汤)elderlyknee osteoarthritisclinical effectquality of life
万方数据
维普
