Research Progress of Xiaoqinglong Decoction(小青龙汤)and Its Predictive Analysis of Quality Markers
Xiaoqinglong Decoction(小青龙汤)is a classic formula for relieving exterior and dissipating cold and warming lung and resolving fluid retention,mainly treating syndrome of external cold and internal fluid.Modern pharmacology research has found that Xiaoqinglong Decoction has the effects of anti-allergy,anti-inflammatory,relieving cough and asthma.It is mainly used in the treatment of respiratory disease in clinic,among which the treatment effect of allergic diseases is better,but there is less research on the material basis of its efficacy at present.Based on this,this article reviewed the research progress of chemical composition,pharmacological action,clinical application and quality control of Xiaoqinglong Decoction in recent years,and predic-ted the quality markers of Xiaoqinglong Decoction according to the"five principles"of quality markers.The results suggest that ephedrine,pseudoephedrine,methylephedrine,norpseudoephedrine,cinnamaldehyde,paeoniflorin,albiflorin,schizandrin,6-gin-gerol,liquiritin and glycyrrhizic acid has strong specificity and high measurability,which can be used as the quality markers of Xi-aoqinglong Decoction,in order to provide a basis for the improvement of the quality evaluation system of Xiaoqinglong Decoction.