Research Progress on Sini Powder(四逆散)and Its Single Active Ingredient with Antidepressant Effects
Depressive disorder is a kind of mental disorder characterized by low mood and loss of pleasure,accompanied by cognitive,behavioral and autonomic symptoms.It has the characteristics of high prevalence,high disability rate,high suicide rate and high recurrence rate,which seriously affects the quality of life of patients and is one of the difficulties in clinical treatment.Sini Powder(四逆散)is a classic prescription for soothing liver.It is composed of Chanhai(Bupleuri Radix),Baishao(Paeoniae Radix Alba),Zhishi(Aurantii Fructus Immaturus)and Zhigancao(Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle)at an equal ratio of 1∶1∶1∶1.It is widely used in various diseases caused by liver depression and Qi stagnation,and the curative effect is exact.Studies have found that Sini Powder can achieve the purpose of antidepressant by regulating multiple targets such as neural circuit,neurotransmitter,immune inflammatory response and ion transport.This article summarized the antidepressant mechanism and clinical application of Sini Powder and its active ingredients,aiming to provide reference for the treatment of de-pressive disorder with traditional Chinese medicine.
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维普
