Clinical and Experimental Research Status in Treatment of Psoriasis by Huangqin(Scutellariae Radix)
Effective treatments for psoriasis are urgent issues that need to be explored,and Huangqin(Scutellariae Radix)has a long history in the treatment of psoriasis-like diseases.Based on the current status of clinical and experimental research on Huangqin(Scutellariae Radix)in the treatment of psoriasis both at home and abroad,this paper comprehensively evaluated its clinical efficacy,means of administering the treatment and its safety,summarized the mechanism of action of its main active ingre-dients,analyzed the difficulties faced in its current application and the shortcomings of existing research,and looked forward to the development of its development trend.In clinical practice,Huangqin(Scutellariae Radix)is effective and safe in the treatment of psoriasis,and it is mostly administered in the form of a compound decoction for oral administration or external cleansing.In terms of experimental research,studies were mainly conducted on Huangqin(Scutellariae Radix)extract and Huangqin(Scutellariae Ra-dix)monomer,among which,the study on Huangqin(Scutellariae Radix)monomer mainly focused on baicalin.Several cellular experiments have found that it can inhibit the overproliferation and abnormal apoptosis of keratin-forming cells,which can lead to the improvement of psoriasis lesions.In addition,several animal experimental studies have shown that baicalin can improve the erythema,scaling and thickness of the epidermis in mice with psoriasis induced by imiquimod.In terms of toxicological studies,there are reports of hepatic and renal toxicity and sensitization of baicalin,as well as numerous results which can not show signifi-cant toxicological changes,and the safety evaluation of baicalin has not yet reached a unified conclusion.
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