首页|龙骨牡蛎汤加味治疗慢性萎缩性胃炎的疗效及对中医证素影响

龙骨牡蛎汤加味治疗慢性萎缩性胃炎的疗效及对中医证素影响

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目的 分析龙骨牡蛎汤加味治疗慢性萎缩性胃炎的疗效及对中医证素的影响.方法 选取2022年1月—2022年12月安徽医科大学附属阜阳人民医院中西医结合科收治的112例患有慢性萎缩性胃炎的患者作为研究对象,随机分为两组,每组56例患者,对照组采用胶体果胶铋胶囊进行治疗,观察组实施龙骨牡蛎汤加味进行治疗.比较两组患者的临床疗效.结果 观察组总有效率94.64%,高于对照组82.14%,差异有统计学意义(P<0.05).观察组中医证候积分均低于对照组,组间差异有统计学意义(P<0.05).观察组内皮素(Endothelin,ET)、表皮生长因子(Epidermal Growth Factor,EGF)低于对照组,降钙素基因相关肽(Calcitonin gene related peptide,CGRP)高于对照组,差异有统计学意义(P<0.05).观察组炎症因子水平均低于对照组,差异有统计学意义(P<0.05).观察组治疗后匹兹堡睡眠质量调查表(Pittsburgh sleep quality index,PSQI)评分各项均低于对照组,差异有统计学意义(P<0.05).结论 患有慢性萎缩性胃炎的患者通过龙骨牡蛎汤加味治疗后效果更佳,能有效改善患者的胃功能,减轻机体炎性反应,促进患者康复,具有较高的临床应用价值.
Effect of Modified Longgu Muli Decoction(龙骨牡蛎汤加味)on Chronic Atrophic Gastritis and Its Influence on TCM Syndrome Elements
Objective To analyze the effect of Modified Longgu Muli Decoction(龙骨牡蛎汤加味)on chronic atrophic gastri-tis and its influence on TCM syndrome elements.Methods A total of 112 patients with chronic atrophic gastritis admitted to the hospital from January 2022 to December 2022 were selected as research objects and randomly divided into two groups with 56 pa-tients in each group.The control group was treated with bismuth colloid pectin capsule,and the observation group was treated with Modified Longgu Muli Decoction.The clinical effects of the two groups were compared.Results The total effective rate of the observation group was 94.64%,which was higher than that of the control group(82.14%),and the difference was statistically significant(P<0.05).TCM syndrome scores in the observation group were lower than those in the control group,and the differ-ence between groups was statistically significant(P<0.05).The levels of endothelin(ET)and epidermal growth factor(EGF)of the observation group were lower than those of the control group,while the level of calcitonin gene related peptide(CGRPP)of the observation group was higher,and the difference was statistically significant(P<0.05).The levels of inflammatory factors in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The Pitts-burgh sleep quality index(PSQI)scores of the observation group were lower than those of the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion The patients with chronic atrophic gastritis can get better effects after the treatment of Modified Longgu Muli Decoction which can effectively improve the gastric function of patients,reduce the inflammatory response of the body and promote the rehabilitation of patients,and has high clinical application value.

chronic atrophic gastritisModified Longgu Muli Decoction(龙骨牡蛎汤加味)gastric functionTCM syndrome element

刘俊、于立恒、华自森、洪飞、孙莉

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安徽医科大学附属阜阳人民医院,安徽阜阳 236000

南京市浦口区中医院,江苏南京 210000

慢性萎缩性胃炎 龙骨牡蛎汤加味 胃功能 中医证素

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(12)