Exploring Clinical Efficacy of Wenpi Kaiqiao Tongluo Prescription(温脾开窍通络方)in Treatment of Senile Dementia and Its Correlation with Intestinal Flora Based on Theory of"Brain-Gut Axis"
Objective To explore the clinical efficacy of Wenpi Kaiqiao Tongluo Prescription(温脾开窍通络方)in the treat-ment of senile dementia and its correlation with intestinal flora based on the theory of"brain-gut axis".Methods Forty Alzhei-mer's disease patients in the outpatient treatment from May 2020 to July 2022 were selected and divided into treatment group(20 cases)and control group(20 cases)by random number table method.The control group received conventional Western medicine treatment,and the treatment group received Wenpi Kaiqiao Tongluo Prescription on the basis of the control group.The two groups were treated for 8 weeks,and the TCM syndrome scores,cognitive function,intestinal flora related indexes,inflammatory response,adverse reactions and clinical efficacy were compared between the two groups.Results After treatment,the scores of main symp-toms and secondary symptoms and total scores of two groups were decreased(P＜0.05),and the scores of the treatment group was lower(P＜0.05).After treatment,the mini-mental state examination(MMSE)scores of both groups were increased(P＜0.05),but there was no significant difference in MMSE scores between the two groups(P＞0.05).After treatment,the plasma levels of serotonin were increased in both groups(P＜0.05),but there was no statistical significance in the plasma levels of sero-tonin between the two groups(P＞0.05).After treatment,the serum levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor a(TNF-α)were decreased in both groups(P＜0.05),and those were lower in the treatment group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).There was no significant difference in total effective rate between the two groups(P＞0.05).Conclusion Based on the theory of"brain-gut axis",the study explored that Wenpi Kaiqiao Tongluo Prescription could improve the cognitive function of patients with senile dementia,reduce inflammation and regulate intestinal flora with remarkable efficacy and good safety.
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