首页|炙法对中药化学成分影响的研究进展

炙法对中药化学成分影响的研究进展

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炙法,作为一种传统的中药炮制方法,通过对中药材进行加热处理,以改变其内部化学成分和药理作用。然而,不同的炙法、不同的中药材以及不同的炙制条件都可能对化学成分产生不同的影响。为了阐明炙法对中药化学成分的具体影响及其作用机制,许多学者运用现代分析手段对该方法炮制后的中药化学成分变化进行了研究。根据炙法所使用的辅料不同,从盐炙、醋炙、酒炙、蜜炙、姜炙和油炙这六种炙法入手,对相关代表性药物的化学成分变化进行了综述,并与各位学者研究成果进行了对比。结果表明,炙法对中药化学成分的影响具有显著性和复杂性,显著性表现为:相关研究测定了中药的有效成分含量变化,结果显示,炮制后的中药其成分会发生量变和质变,进而增强中药的药理活性或改变药物的作用趋向;复杂性表现为:炮制后中药有效成分含量的增减机制没有得到科学解释,化学结构变化研究仍存在不足之处。旨在为炙法炮制对中药化学成分的研究提供参考和启示,为完善炙法炮制机制的研究提供参考依据。
Research Progress on Effect of Stir-Frying with Liquid Adjuvant Method on Chemical Components of Traditional Chinese Medicine
Stir-frying with liquid adjuvant method is a traditional processing method,which heats Chinese medicinal materi-als(CMM)to change the internal chemical composition and pharmacological effects.However,different stir-frying with liquid adjuvant methods,different conditions and different CMM may have different effects on the chemical composition.In order to elu-cidate the specific impact and mechanism of stir-frying with liquid adjuvant method on the chemical components of CMM,many scholars have used modern analytical methods to study the changes in the chemical components of CMM processed by stir-frying with liquid adjuvant method.Based on the different auxiliary materials used in processing,this article started with six processed methods(stir-frying with salt,vinegar,wine,honey,ginger and oil),reviewed the changes in the chemical composition of related representative CMM,and compared them with the research results of various scholars.The results showed that the components of processed CMM would undergo quantitative and qualitative changes,thereby enhancing the pharmacological activity of CMM or changing the direction of its action.The complexity was manifested as the lack of scientific explanation for the mechanism of in-crease and decrease in the content of active ingredients in CMM after processing,and there were still shortcomings in the study of chemical structure changes.The purpose of this article was to provide reference and inspiration for the study of the chemical com-position of CMM processed by stir-frying with liquid adjuvant method and to provide reference basis for improving the research on the mechanism of stir-frying with liquid adjuvant method.

stir-frying with liquid adjuvant methodChinese medicinal materialschemical constituentsresearch progress

白浩东、张子东、孙延平、祝明涛、张志宏、曾元宁、王秋红、匡海学

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黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨 150040

广州大学生命科学学院,广东 广州 510006

广东药科大学中药学院,广东省中药饮片规范化炮制工程技术研究中心,广东 广州 510006

炙法 中药 化学成分 研究进展

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(12)