Exploring Scientific Connotation of Kidney Dominating Bone and Producing Marrow Regulating Mechanism of Bone Remodeling by Kidney-Tonifying Chinese Medicine Based on Single Cell Level
Bone remodeling is a dynamic process that primarily involves the coupling of bone formation mediated by osteo-blasts and bone resorption mediated by osteoclasts,as well as the participation of bone microenvironments such as vascular endo-thelial cells and immune cells.This process is a key link in maintaining bone homeostasis.In pathological conditions such as ag-ing or estrogen deficiency,the dysregulation of bone remodeling disrupts the balance between bone formation and resorption,resul-ting in reduced bone mass and bone mineral density.This imbalance contributes to the development of bone metabolic disorders such as osteoporosis.Bone remodeling involves various cell types derived from bone marrow mesenchymal stem cells and hemato-poietic stem cells.These include osteogenic and osteoclastic cells,as well as vascular endothelial and immune cells.Throughout their development and differentiation,these cells give rise to different subtypes,exhibiting high heterogeneity and performing di-verse functions in the regulation of bone remodeling.According to the theory of kidney governing bone marrow in traditional Chi-nese medicine,kidney-tonifying Chinese medicine is considered the primary therapeutic approach to regulate bone remodeling.These medicines are believed to have the capacity to regulate various cells involved in bone remodeling.This study initiates with an exploration into the advancements in heterogeneity analysis of bone remodeling cells.It delves into the potential regulatory effects of kidney-tonifying Chinese medicine on the heterogeneous differentiation and functionality of bone remodeling cells.Furthermore,it investigates the mechanisms and targets underlying the treatment of bone metabolic disorders by kidney-tonifying Chinese medicine,offering methodologies and insights to elucidate the novel cellular mechanisms of kidney regulation over bone marrow.
kidney-tonifying Chinese medicinebone remodelingsingle cellbone marrowosteoporosis
万方数据
维普
