Research Progress of Regulating Mitochondrial Quality Control and Inhibiting Cardiomyocyte Apoptosis by Traditional Chinese Medicine
Cardiomyocyte apoptosis is an important pathological change in cardiovascular diseases and has an important im-pact on the development of cardiovascular diseases.Mitochondria are abundant in cardiomyocytes,which are not only the main places of energy metabolism of cardiomyocytes,but also provide a lot of energy for the normal life activities of the heart.It is also the center of endogenous apoptosis,which is closely related to myocardial apoptosis.In cardiovascular diseases,mitochondrial dysfunction and morphological changes can lead to increased apoptosis of cardiomyocytes.The regulation of mitochondrial quality control can maintain mitochondrial homeostasis in damaged cells,exert mitochondrial function,inhibit cardiomyocyte apoptosis and slow down the process of cardiovascular disease.In the treatment of cardiovascular diseases,traditional Chinese medicine can reg-ulate mitochondrial quality control and inhibit cardiomyocyte apoptosis through multiple approaches and targets.Mitochondrial bi-ogenesis,mitochondrial dynamics and mitochondrial autophagy are three important components of mitochondrial quality control.This paper elaborated the influence of mitochondrial quality control on cardiomyocyte apoptosis from these three aspects and sum-marized the inhibition of cardiomyocyte apoptosis by traditional Chinese medicine through regulating mitochondrial quality con-trol,in order to clarify the mechanism of traditional Chinese medicine and provide new ideas and theoretical basis for traditional Chinese medicine treatment of cardiovascular diseases possibly.
traditional Chinese medicinecardiomyocyte apoptosismitochondrial quality controlcardiovascular diseasesmi-tochondria
万方数据
维普
