Clinical Efficacy of Lianhua Qingke Tablets(连花清咳片)in Auxiliary Treatment of Acute Bronchitis(Phlegm Heat Obstructing Lung Syndrome)and Its Impact on Serum Inflammatory Cytokine Levels
Objective To observe the clinical efficacy of Lianhua Qingke Tablets(连花清咳片)as an auxiliary treatment for a-cute bronchitis(phlegm heat obstructing lung syndrome)and its impact on serum inflammatory cytokine levels.Method Eighty patients with acute bronchitis(phlegm heat obstructing lung syndrome)who met the inclusion criteria for this study were randomly divided into two groups using a number table method.The control group received symptomatic treatment with conventional West-ern medicine,while the observation group received oral administration of Lianhua Qingke Tablets on the basis of symptomatic treatment with conventional Western medicine.The traditional Chinese medicine syndrome scores(cough,sputum characteristics,24-hour sputum volume,fever,wheezing,dyspnea),duration of individual symptoms,blood routine indicators(lymphocyte per-centage,neutrophil percentage,white blood cell count),oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA),nitric oxide(NO)],and serum inflammatory cytokines[tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-8(IL-8),interferon-y(IFN-γ)]of two groups were compared,and the total effective rate and drug safety be-tween the two groups.Result After treatment,the scores of cough,sputum characteristics,24-hour sputum volume,fever,wheez-ing,dyspnea,the levels of neutrophil percentage,white blood cell count,the levels of MDA,TNF-α,IL-4 and IL-8 in both groups were lower than those before treatment(P＜0.05),and the scores and the levels in the observation group were lower than those of the control group(P＜0.05).The levels of lymphocyte percentage,SOD,NO and IFN-γ after treatment in both groups were all higher than those before treatment(P＜0.05),and the levels in the observation group were higher than those of the con-trol group(P＜0.05).The duration of cough,expectoration,fever,wheezing and lung rales in the observation group after treat-ment was shorter than that in the control group(P＜0.05).The total effective rate of the observation group(97.5％)was higher than that of the control group(80.0％)(P＜0.05).During the medication period,there were no adverse reactions related to the medication in both groups.Conclusion The combination of Lianhua Qingke Tablets and conventional Western medicine has a clear therapeutic effect on acute bronchitis(phlegm heat obstructing lung syndrome),which can quickly alleviate clinical symp-toms and signs,inhibit inflammatory reactions in the body,reduce oxidative stress damage,help to shorten the course of the dis-ease and promote the disease recovery.
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