Effects of Lingnan Scalp on Serum Brain-Derived Neurotrophic Factor,Interleukin-6 and Cognitive Function in Patients with Post-Stroke Cognitive Impairment of Qi Deficiency and Blood Stasis Type
Objective To observe the clinical efficacy of Lingnan scalp acupuncture in treating cognitive impairment in patients with Qi deficiency and blood stasis type stroke,and its effect on serum levels of brain derived neurotrophic factor(BDNF)and interleukin-6(IL-6).Methods A total of 120 patients included in the study were randomly divided into a treatment group and a control group.Both groups received secondary stroke prevention and oral administration of donepezil hydrochloride tablets.The treatment group also received Lingnan scalp acupuncture treatment,while the control group received conventional scalp acupunc-ture treatment.The cognitive function was assessed using the Minimum Mental State Examination(MMSE)and Montreal Cogni-tive Assessment(MoCA)before treatment,4 and 8 weeks after treatment.The Modified Barthel Index(MBI)was used to assess activities of daily living,the Fugl-Meyer motor function scale was used to assess motor function and the Qi deficiency and blood stasis syndrome scale was used to assess symptom improvement.The changes in serum BDNF and IL-6 concentrations were de-tected and the clinical efficacy was evaluated using MMSE scores.Results The total effective rate of the control group(81.67％)was lower than that of the treatment group(95.00％),and the treatment group was better than the control group in terms of effica-cy(P＜0.05).After treatment,the scores of MMSE,MOCA and MBI and serum BDNF level in two groups increased(P＜0.05)and the scores of traditional Chinese medicine symptoms and the levels of IL-6 decreased(P＜0.05).The difference between two groups was more obvious(P＜0.05).After treatment,the Fugl-Meyer scores were improved in two groups(P＜0.05),and there was no obvious difference between two groups(P=0.065,P＞0.05).Conclusion Lingnan scalp acupuncture can effective-ly improve the cognitive function of daily living in patients with post-stroke cognitive impairment due to Qi deficiency and blood stasis,and regulate the serum levels of BDNF and IL-6.It is suitable for clinical application.
Lingnan scalp acupunctureQi deficiency and blood stasis typepost-stroke cognitive impairmentBNDFIL-6
万方数据
维普
