Inhibitory effects of total ginsenoside on serum oxidation level of pulmonary fibrosis in rats
Objective To observe the protective effects and mechanism of total ginsenoside on pulmonary fibrosis induced by monocrotaline in rats.Methods Seventy-five Sprague Dawley rats were randomly divided into sham control,model and total ginsenosides(40,80 and 160 mg/kg)groups.Single subcutaneous injection of monocrotaline(50 mg/kg)into rat neck and back was conducted to establish a pulmonary fibrosis animal model.Twenty-one days later,the pulmonary indexes were calculated and the pathological changes of lung tissue were observed.The activity of superoxide dismutase (SOD),nitric oxide synthase (NOS) and myeloperoxidase (MPO),levels of total antioxidant capacity (T-AOC) and hydroxy radical (· OH) in serum of rats were detected.Results Compared with the sham control group,after modeling for 21 days,the pulmonary indexes in model group was significantly increased with obvious alveolitis and pulmonary fibrosis.The activity of MPO and NOS and the level of · OH were increased,but the activity of SOD and the level of T-AOC in serum of rats were decreased.Compared with model group,the pulmonary indexes in total ginsenosides (80 and 160 mg/kg)group were significantly decreased,and the degree of alveolitis and pulmonary fibrosis was mitigated.The activity of MPO and NOS and the level of · OH were decreased,while the activity of SOD and the level of T-AOC in serum of rats were increased.Conclusion Total ginsenosides could improve the degree of pulmonary fibrosis in rats induced by monocrotaline.The mechanism might be related to the increased antioxidant capacity of organisms.
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NSTL
万方数据
维普
