摘要
目的 利用古今医案云平台探讨我国南北中医治疗肠癌的用药异同,为肠癌的中医药诊疗提供参考.方法 分别检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普中文期刊服务平台(VIP)及中国生物医学文献数据库(CBM),筛查建库至2023年8月肠癌中医药治疗的名医医案,利用Excel 2019、古今医案云平台(V2.3.7)挖掘肠癌南北用药异同.结果 纳入文献141篇,涉及方剂184首,包含中药316味.南北高频用药包括白术、茯苓、黄芪等,南方茯苓、薏苡仁、白花蛇舌草、猕猴桃根等药排序较靠前,北方黄芪、党参、当归等频次较高;四气五味、归经以平、温、寒、甘、苦、辛、脾、肝、肺为主;功效方面,南北均以清热解毒药、健脾益气药、燥湿化痰药为主,南方还重视健脾、宁心,北方更重视润肠通便、行滞通痹.关联规则分析显示二者的药物组合主要以白术为中心,黄芪、茯苓分别与白术呈强组方关联.此外,南方的白术与薏苡仁及北方的陈皮与白术、黄芪也存在较强的组方关联.结论 肠癌南北用药均以清热解毒、健脾燥湿为法,此外,南方用药更重视健脾、宁心,北方用药兼顾润肠通便、行滞通痹.
Abstract
Objective The ancient and modern medical record cloud platform was used to explore the similarities and differences of traditional Chinese medicine(TCM)in the treatment of colorectal cancer(CRC)between the North and South of China so as to provide reference for TCM diagnosis and treatment of CRC.Methods The CNKI,Wanfang,VIP,and CBM were retrieved from the establishment until August 2023 to screen the medical cases of famous physicians treating CRC with TCM.The similarities and differences between the North and South medication of CRC were explored by using Excel 2019 and the ancient and modern medical record cloud platform(v2.3.7).Results 141 articles with 184 prescriptions were included,including 316 Chinese medicines.The high-frequency drugs used in the North and South included Atractylodes macrocephala,Poria cocos,Astragalus membranaceus,etc.Poria cocos,coix seed,Hedyotis diffusa,kiwifruit root ranked higher in the South,while Astragalus membranaceus,Codonopsis pilosula,Angelica sinensis had higher frequency in the North.The four natures,five flavors,and meridian tropism were mainly composed of flat,warm,cold,sweet,bitter,pungent,spleen,liver,and lung.In terms of efficacy,both the North and the South were mainly composed of heat clearing and toxin removing drugs,spleen invigorating and qi replenishing drugs,and dampness and phlegm removing drugs.The South also attached importance to spleen strengthening and heart calming,while the North attached more importance to moisten intestines to relieve constipation as well as promote stagnation and unblock obstruction.Association rule analysis showed that the drug combination mainly centered on Atractylodes macrocephala,and Astragalus membranaceus and poria cocos were strongly related to Atractylodes macrocephala.In addition,Atractylodes macrocephala and coix seed in the South while tangerine peel and Atractylodes macrocephala and Astragalus membranaceus in the North also had strong correlation.Conclusion The medication for CRC in both the North and the South is based on the principles of clearing heat and removing toxins,invigorating the spleen and drying dampness.In addition,medication of the South pays more emphasis on invigorating the spleen and calming the heart,while the North takes into account the principles of moistening intestines to relieve constipation and promoting stagnation and unblocking obstruction.
基金项目
广州市科技局市校(院)联合资助项目(202201020515)
国家科技期刊平台
NSTL
万方数据