In order to promote the application and development of classic prescription in traditional Chinese medicine oncology,improve the therapeutic effect of traditional Chinese medicine on cancer pain,and exert the advantage of classic prescription to improve the quality of life of patients with cancer pain,this article collected and arranged clinical literature on classic prescription in the treatment of cancer pain.This article conducted syndrome differentiation through formula effect assessment from the perspective of classic prescription and syndrome.The differentiation and treatment of cancer pain were classified and summarized based on six-meridian syndrome differentiation system,and the six-meridian syndrome differentiation and treatment laws of cancer pain were reviewed and explored,in order to provide a literature basis for the diagnosis and treatment plan of cancer pain with the stepwise treatment of six-meridian syndrome differentiation.