Radiotherapy is one of the important means of cancer treatment.However,radiation inflammation and tumor radioresistance caused by high-dose radiotherapy seriously affect the patients'treatment compliance and success rate.Radiosensitizer can effectively increase the radiosensitivity of tumor cells and promote the killing effect of radiation on tumor cells,which is of great importance in clinical practice.This paper reviewed the sensitization mechanisms of traditional Chinese medicines(TCMs)as radiosensitizers and their potential application value in cancer radiotherapy in the past five years,and screened candidate TCMs that could be used as new radiosensitizers.Scientific databases such as PubMed,Scopus,Google Scholar,and China National Knowledge Infrastructure(CNKI)were searched by using keywords,and the data and results of relevant basic and clinical research were reviewed.It was found that there was a certain foundation for the research of TCMs as radiosensitizers at domestic and abroad.Monomers,prescriptions,herbal extracts,and novel nanomedicines showed potential application value.The radiosensitization mechanisms were mainly related to regulate cancer cell apoptosis pathways or genes of cell cycle arrest.
维普
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