岭南火针疗法预治疗化疗相关性恶心呕吐的随机对照试验
The Randomized Controlled Trial of Lingnan Fire Needle in the Pretreatment of Chemotherapy-Induced Nausea and Vomiting
肖青娥 1陈子茵 2焦俊玥 3权婧宜 1陈宣尚 1蓝家楠 4关洁珊 4王澍欣 4林诗雨 4林国华4
作者信息
- 1. 广州中医药大学第一临床医学院,广东 广州 510405
- 2. 广州中医药大学基础医学院,广东 广州 510405
- 3. 江西省体育科学医疗中心,江西 南昌 330038
- 4. 广州中医药大学第一临床医学院,广东 广州 510405;广州中医药大学第一附属医院,广东 广州 510405;广东省中医临床研究院,广东 广州 510405
- 折叠
摘要
目的 观察岭南火针疗法预防性治疗化疗相关性恶心呕吐(chemotherapy-related nausea and vomiting,CINV)的临床疗效.方法 将60例既往出现过CINV的恶性肿瘤患者采用随机数字表法结合信封法分为对照组和治疗组各30例.对照组在化疗前30 min静脉推注盐酸托烷司琼注射液5 mg;治疗组在对照组的基础上于化疗前1天、输注化疗药当天前30 min各行岭南火针疗法一次,此为一个疗程.评估两组患者化疗前1天至化疗后第5天出现恶心呕吐的频率和程度、呕吐功能性生活指数(functional living index emesis,FLIE)评分值(恶心维度)以及化疗前 1 天和化疗后第 5 天的卡氏功能状态(karnofsky performance status,KPS)评分.结果 治疗组从化疗后第1天到第5天出现的恶心、呕吐程度的缓解作用均优于对照组(P＜0.05),治疗组在维持患者的体能状态上优于对照组(P＜0.05).结论 岭南火针疗法联合盐酸托烷司琼注射液预治疗CINV疗效更优,特别是对呕吐的缓解,在维持体能状态方面疗效优于单纯使用西药治疗.
Abstract
Objective To explore the clinical efficacy of Lingnan fire needle on chemotherapy-related nausea andvomiting(CINV).Methods 60 patients with a history of CINV were randomly divided into a control group and a treatment group,with 30 cases in each group,using random number table method combined with envelope method.In the control group,5 mg tropisetron hydrochloride injection was injected intravenously 30 minutes before chemotherapy.On the basis of the control group,the treatment group was treated with Lingnan fire needle one day before chemotherapy and 30 minutes before the infusion of chemotherapy drugs.This is one course of treatment.The frequency and degree of nausea and vomiting and the functional living index emesis(FLIE)score(nausea dimension)from 1 day before chemotherapy to 5 days after chemotherapy were recorded,and the karnofsky performance status(KPS)score was evaluated on 1 day before chemotherapy and the fifth day after chemotherapy.Results The relief of nausea and vomiting in the treatment group from the first day to the fifth day after chemotherapy was better than that in the control group(P＜0.05).The treatment group was better than the control group in maintaining the physical state of patients(P＜0.05).Conclusion Lingnan fire needle combined with tropisetron hydrochloride injection is more effective in the pretreatment of CINV,especially vomiting,and the efficacy on maintaining physical state is superior to western medicine alone.
关键词
岭南火针疗法/化疗相关性恶心呕吐/预治疗/临床疗效Key words
Lingnan fire needle/chemotherapy-induced nausea and vomiting/pretreatment/clinical efficacy引用本文复制引用
基金项目
国家教育部人文社会科学研究项目(20YJCZH089)
广东省基础与应用基础研究基金项目(2022A1515111214)
广东省中医药管理局项目(20221128)
广州市科技厅基础与应用基础研究专题(SL2023A04J01521)
岭南张氏针灸流派传承工作室项目(2017LP02)
出版年
2024
国家科技期刊平台
NSTL
万方数据