首页|Effect of volatile oil from Blumea Balsamifera (L.) DC.leaves on wound healing in mice
Effect of volatile oil from Blumea Balsamifera (L.) DC.leaves on wound healing in mice
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
OBJECTIVE:To assess the effectiveness of violate oil from Blumea Balsamifera (L.) DC.leaves (BB oil) on wound healing in mice.METHODS:Undiluted BB oil and its diluted solutions with olive oil to 1/5 and 1/10 to yield BB oil1/5 and BB oil1/10 were applied to the wounded skin before wound healing conditions were assessed by healing rate,histopathology,and contents of collagen,hydroxyproline,and Neuropeptide Substance P (SP).All above results were compared with the efficacies of the control,pure olive oil,basic fibroblast growth factor (BFGF),and cream of Jing Wan Hong (JWH).RESULTS:BB oil1/5 and BB oil1/0 improved wound contraction and closure.Histopathology study further confirmed a desirable histological organization of wound tissues.BB oil1/5 and BB oil1/10 reduced the number of inflammatory cells,increased wound-healing rates,and significantly increased the hydroxyproline content.Both BB oil1/5 and BB oil1/10 improved formation of collagen,and reduced the frequency of fibroblasts.Moreover,BB oil1/5 and BB oil1/10 markedly promoted SP expression.However,undiluted BB oil may induce skin thickening and hardening,inhibite collagen synthesis and delay complete skin wound healing.CONCLUSION:The BB oil1/5 and BB oil1/10 promoted capillary regeneration,blood circulation,collagen deposition,granular tissue formation,epithelial deposition,and wound contraction.The mechanism underlying the action might be related to induction of SP secretion,and the proliferation and differentiation of mesenchymal cells.
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China
Medicinal Efficacy Evaluation Laboratory, Hainan Provincial Engineering Research Center for Ainaxiang(Herba Blumeae Balsamiferae), Danzhou 571737, China
Key Laboratory of Tropical Crop Gene Resources and Germplasm Enhancement of Ministry of Agriculture, Danzhou 571737, China
College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510000, China
展开 >
Fundamental Scientific Research Funds for Chinese Academy of Tropical Agricultural Sciences —Tropical Crops Genetic ResourceNatural Science Fund of Hainan ProvinceNatural Science Fund of China
NETL
NSTL
万方数据
