首页|Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

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Worldwide,as the population age,osteoporosis is becoming increasingly common,and osteoporotic fractures have a significant economic burden.Postmenopausal women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal years.In this regard,we hypothesize rational combination of acupuncture and Traditional Chinese Medicine(TCM)in the form of herbal extract could prevent osteoporosis in women.Estrogen deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts,the bone-resorbing cells,and simultaneously inhibits the viability and function of osteoblasts,the bone-forming cells.The most potent inflammatory cytokine in skeletal homeostasis is the receptor activator of nuclear factor kappa B ligand(RANKL)that stimulates osteoclast function.Conversely,the canonical Wnt pathway is essential for osteoblastogenesis and bone formation,and estrogen deficiency leads to diminished functioning of this pathway.TCM and acupuncture could target the RANKL and the Wnt pathway in favorable ways to prevent the accelerated bone loss experienced during the early menopausal stage and promote the gain in bone mass in postmenopausal women.In this review,we propose a rational combination of specific TCM and acupuncture targeting those signaling molecules/pathways by the drugs that are in clinical use for the treatment of postmenopausal osteoporosis.Our rational approach revealed that Danshen(Radix Salviae Miltiorrhizae)could exert a synergistic effect with acupuncture.We then propose a translational path for developing the putative combination in women with postmenopausal osteoporosis to curtail the risk of osteoporotic fractures.

medicine,traditionalosteogenicanti-resorptivereview

REN Ping、WANG Quanwu、BAI Wei、SUN Miao、LIU Zheling、GAO Ming、WANG Liang、PENG Bo、XU Liguang

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Department of Health Management,the Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine,Changchun 130117,China

Department of Dirty Tuina,the affiliated Hospital to Changchun University of Chinese Medicine,Changchun 130117,China

Department of Acupuncture,the affiliated Hospital to Changchun University of Chinese Medicine,Changchun 130117,China

Department of Rehabilitation Medicine,the 924th Hospital of the PLA Joint Logistic Support Force,Foshan 528226,China

Department of College of Acupuncture and Massage,Changchun University of Chinese Medicine,Changchun 130117,China

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2024

10.19852/j.cnki.jtcm.20230904.006

中医杂志(英文版)
中国中医药学会 中国中医研究院

中医杂志(英文版)

影响因子：0.855
ISSN：0255-2922
年,卷(期)：2024.44(1)
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