Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis:a systematic review and Meta-analysis

ZHOU Mingwang ¹DONG Zhuanli ²WEI Changhao ³FENG Lufang ⁴WANG Xiaoping ⁵LIU Haiping ⁵JI Xing ⁵YANG Kehu ⁴LI Shenghua⁶

扫码查看

作者信息

1. Department of Orthopaedics,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China
2. Department of Quality Management,Lanzhou Petrochemical General Hospital,Lanzhou 730050,China
3. Department of Orthopaedics,Lanzhou Petrochemical General Hospital,Lanzhou 730050,China
4. Evidence-Based Social Science Research Center,School of Public Health,Lanzhou University,Lanzhou,730000,China;Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province,Lanzhou 730000,China
5. Center for Translational Medicine,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China
6. Department of Orthopaedics,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China
折叠

Abstract

OBJECTIVE:To assess the efficacy and safety of extracorporeal shockwave therapy(ESWT)combined with sodium hyaluronate(HA)for the treatment of knee osteoarthritis(KOA).METHODS:PubMed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,and SinoMed were searched from inception to July 2020.The quality of the randomized controlled trials was evaluated independently by two reviewers according to the criteria in the Cochrane Collaboration for Systematic Reviews.The identified articles were then screened individually using EndnoteX9 for eligibility in this Meta-analysis.The heterogeneity among the articles was evaluated using 12.RESULTS:A total of 17 studies,comprising 2000 individuals,were included in this Meta-analysis.The results showed that a significant improvement was observed in knee pain and function based on the clinical efficacy of ESWT combined with HA.Statistical analysis of clinical efficacy showed that[relative risk(RR)=1.21,95％confidence interval(Cl)(1.12,1.30),P＜0.01].Statistical analysis of visual analog scale showed that[standardized mean difference(SMD)=-2.84,95％Cl(-4.01,-1.66),P＜0.01].Western Ontario and McMaster University osteoarthritis index statistical analysis showed that[SMD=-1.57,95％Cl(-2.52,-0.61),P＜0.01].Lysholm score statistical analysis showed that[SMD=1.71,95％Cl(0.98,2.44),P＜0.01].In addition,only minor side effects,such as redness and swelling of the skin,were observed.CONCLUSIONS:Medium to low quality evidence showed that ESWT combined with HA offers an inexpensive,well-tolerated,safe,and effective method to improve pain and functionality in patients with KOA.However,tightly controlled,randomized,large multicenter trials are warranted to validate the current findings.

Key words

osteoarthritis,knee/randomized controlled trial/extracorporeal shockwave therapy/hyaluronic acid/Meta-analysis

引用本文复制引用

基金项目

Natural Science Foundationfunded Project()

Constitution Theraphy(81260546)

Construction Project of Chinese Medicine Inheritance Innovation Platform(Gan Wei Chinese Medicine Letter[2020]203)

Gansu Provincial Science and Technology Plan Project(18JR2FA009)

出版年

2024

中医杂志(英文版)

中国中医药学会中国中医研究院

中医杂志(英文版)

影响因子：0.855

ISSN：0255-2922

参考文献量6

段落导航