首页|Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

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Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep coma.SAE is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive function.The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood-brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial activation.Increasing evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after sepsis.Here,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

sepsis-associated encephalopathycognitive dysfunctioncomplementary therapiesneuroinflammatory diseasesmedicine,Chinese traditionalreview

LI Zhenxuan、WANG Xuerui、Luis Ulloa、Ayman Youssef、BAI Yunjing、XU Xiaolong、LIU Qingquan

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Department of Infectious Diseases,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China

Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases,Beijing 100010,China

Infection immunity laboratory,Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China

Clinical College of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China

Center for Perioperative Organ Protection,Department of Anesthesiology,Duke University Medical Center,Durham,North Carolina 27710,USA

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Youth Project of National Natural Science Foundation of ChinaSpecial Project of National Natural Science Foundation of ChinaNational Interdisciplinary Innovation Team of TCM under the State Administration of TCMFinancial project of Beijing Municipal Health Commission

8200429282141202ZYYCXTD-D-202201

2024

10.19852/j.cnki.jtcm.20240203.002

中医杂志(英文版)
中国中医药学会 中国中医研究院

中医杂志(英文版)

影响因子：0.855
ISSN：0255-2922
年,卷(期)：2024.44(2)
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