首页|Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)herb pair

Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)herb pair

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OBJECTIVE:To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT)drugs with different proportions.METHODS:Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati,DH)to Taoren(Semen Persicae,TR)(Group A 1∶1,B 2∶3,C 3∶2)were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.RESULTS:A total of 240 primary metabolites were detected.Forty-one differential metabolites involved nine differential metabolic pathways,of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome.These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan),flavonoids,unsaturated fatty acids,and the glycolysis/glycogenesis pathway.CONCLUSION:There are significant differences in the efficacy of different ratios of DT drugs,and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.

metabolomicsmetabolic networks and pathwaysdifferential metabolitesDahuang(Radix Et Rhizoma Rhei Palmati)Taoren(Semen Persicae)kernel drug pairs

WANG Xiang、HUANG Jianping、WANG Yupeng、WANG Qilong、JING Yajiang、ZHANG Gang、PENG Liang、GAO Jing、WANG Hongyan、YAN Yonggang

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Department of Key Laboratory of"Qin Pharmaceutical"Research and Development,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China

Department of Yupeng Shaanxi Haitian Pharmaceutical Co.,Ltd.,Xianyang 712000,China

Department of Acupuncture and Tuina,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China

National Major Natural Science Foundation ProjectProject of the Administration of Traditional Chinese Medicine of Shaanxi ProvinceDiscipline Innovation Team Project on Quality Evaluation and Resource Development of"Qin Medicine",Shaanxi University of Chinese

819735922021-GJ-JC0042019-QN01

2024

10.19852/j.cnki.jtcm.20240423.006

中医杂志(英文版)
中国中医药学会 中国中医研究院

中医杂志(英文版)

影响因子：0.855
ISSN：0255-2922
年,卷(期)：2024.44(3)
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