Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections:a multicenter,randomized controlled study

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外文摘要：OBJECTIVE:To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS:This study recruited 230 adult female patients in the remission phase of rUTIs from five hospitals in China.The patients were randomly allocated to two groups:an individualized Chinese medicine group(n=114)and a control group(n=116).Patients in the Chinese medicine group received individualized Chinese herbs,which were evaluated for syndrome differentiation.Patients in the control group received antibiotic treatment combined with a Chinese medicine placebo.The duration of treatment was three courses of four weeks each,with a three-month subsequent follow-up.UTI recurrence rate,Traditional Chinese Medicine(TCM)syndrome scores,36-item Short Form Survey(SF-36)score,and urine secretory immunoglobulin A(SlgA)were measured and analyzed before and after treatment in each group.RESULTS:Patients from the Chinese medicine group exhibited significant decreases in both short-and long-term UTI recurrence rates compared with the control group(P＜0.05).The changes in TCM syndrome scores between the Chinese medicine and control groups were significant(P＜0.05).The changes in the average SF-36 quality-of-life scores in the Chinese medicine group were also significantly higher than those in the control group after treatment(P＜0.05).The Chinese medicine group also demonstrated a significant increase in urine SlgA expression.CONCLUSION:Taken together,compared to the often-used long-term antimicrobial prophylaxis during the remission stage of rUTIs,treating patients with an individualized Chinese medicine decoction by syndrome differentiation could effectively reduce the recurrence rate,improve the patients'TCM syndrome scores and quality of life,and enhance immunity,which in turn helps to prevent antibiotic resistance.

外文关键词：

urinary tract infectionsmedicine,Chinese traditionalsyndrome differentiationquality of lifeimmunoglobulin A,secretoryrandomized controlled trial

作者：

GU Xiangchen、QIU Meisi、XIE Lin、CHEN Min、DENG Yueyi、ZHANG Changming、JIAN Guihua、WANG Chen、WANG Yi

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作者单位：

Department of Nephrology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China

Department of Nephrology,Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China

Department of Nephrology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

Department of Nephrology,Shanghai Municipal Traditional Chinese Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China

Department of Nephrology,the Sixth People's Hospital Affiliated Shanghai Jiaotong University,Shanghai 200233,China

Department of Nephrology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

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基金：

TCM Guidance Project of Shanghai Science and Technology Commission

项目编号：

13401904600

出版年：

2024

DOI：

10.19852/j.cnki.jtcm.20231024.001

中医杂志(英文版)

中国中医药学会中国中医研究院

中医杂志(英文版)

影响因子：0.855

ISSN：0255-2922

年,卷(期)：2024.44(3)

参考文献量22