首页|Clinical efficacy and gene chip expression analysis of Shenzhu Guanxin recipe granules(参术冠心方颗粒)in patients with intermediate coronary lesions

Clinical efficacy and gene chip expression analysis of Shenzhu Guanxin recipe granules(参术冠心方颗粒)in patients with intermediate coronary lesions

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OBJECTIVE:To evaluate the clinical efficacy and safety of Shenzhu Guanxin recipe granules(参术冠心颗粒,SGR)in treating patients with intermediate coronary lesions(ICL),and to investigate the potential mechanism though a transcriptome sequencing approach.METHODS:ICL patients with Qi deficiency and phlegm stasis were adopted and randomly assigned to a case group or a control by random number generator in a 1:1 randomization ratio to evaluate the clinical efficacy.RESULTS:There was no significant difference between the two groups in coronary computed tomography angiography related indexes in the two groups before and after intervention.Through the gene chip expression analysis,it is finally concluded that there are 355 differential mRNAs(190 up-regulated genes and 165 down regulated genes)when compared the SGR group and placebo group.Through protein-protein interaction network analysis of differentially expressed genes,10 hub genes were finally obtained:CACNA2D2,CACNA2D3,DNAJC6,FGF12,SGSM2,CACNA1G,LRP6,KIF25,OXTR,UPB1.CONCLUSIONS:SGR combined with Western Medicine can be safely used to treat ICL patients with Qi deficiency and phlegm stasis.The possible mechanism of action and relevant gene loci and pathway were proposed.

intermediate coronary lesionsgene expression profilingQi deficiency and phlegm stasisShenzhu Guanxin recipe granules

JIN Xiao、WU Bingxin、LIN Miaoyang、ZHONG Biying、LIN Luoqi、XU Danping

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Department of Traditional Chinese Medicine,the First Affiliated Hospital of Jinan University,Jinan University,Guangzhou 510630,China

Department of Cardiology,Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510000,China

Department of Traditional Chinese Medicine,the Eighth Affiliated Hospital,Sun Yat-Sen University,Shenzhen 518033,China

project of Traditional Chinese Medicine Bureau of Guangdong ProvinceScience and Technology Projects in GuangzhouScience and Technology Innovation Projects of ShenzhenFutian Healthcare Research Project

20221108202201010521JCYJ20220530144212026FTWS2022012

2024

10.19852/j.cnki.jtcm.20240308.004

中医杂志(英文版)
中国中医药学会 中国中医研究院

中医杂志(英文版)

影响因子：0.855
ISSN：0255-2922
年,卷(期)：2024.44(3)
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