首页|Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke

Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke

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OBJECTIVE:To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.METHODS:We searched for all relevant trials published through Oct 7,2022 from seven databases.Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool.A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.RESULTS:A total of 101 studies involving 2148 animals were included.For most studies,primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness[Standardized Mean Difference(SMD)=1.41,95％confidence interval(CI)(0.59,2.23),P=0.0008],numerical density of synapses[SMD=1.55,95％CI(0.48,2.63),P=0.005]compared with non-EA-treated.Similarly,EA could improve parts of biomarkers of synapses,neurogenesis,angiogenesis and neurotrophin activity than the control group(P＜0.05).CONCLUSION:The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity.More rigorous and high quality studies should be conducted in the future.

electroacupuncturebrain plasticityexperimental ischemic strokeanimalsystematic reviewMeta-analysis

XU Yingshan、WU Chunxiao、YU Wei、GUO Hongji、LU Liming、XU Nenggui、TANG Chunzhi

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College of Acupuncture and Massage,Shaanxi University of Chinese Medicine,Middle Section of Century Avenue,Xianyang 712046,China

Department of Encephalopathy,Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou University of Chinese Medicine,Shenzhen 518000,China

Department of Obstetrics and Gynecology,Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518034,China

Medical College of Acu-Moxi and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006,China

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2024

10.19852/j.cnki.jtcm.20240828.008

中医杂志(英文版)
中国中医药学会 中国中医研究院

中医杂志(英文版)

影响因子：0.855
ISSN：0255-2922
年,卷(期)：2024.44(5)