Relative exchangeable copper,a high-quality biomarker for differentiation of Traditional Chinese Medicine syndrome in Wilson's disease

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外文标题：Relative exchangeable copper,a high-quality biomarker for differentiation of Traditional Chinese Medicine syndrome in Wilson's disease

外文摘要：OBJECTIVE:To investigate the value of relative exchangeable copper(REC)in diagnosing Wilson's disease(WD)and to determine its significance in the differentiation of Traditional Chinese Medicine(TCM)syndrome.METHODS:A total of 78 patients with WD were recruited on the same day of the medical visit,and among them,32 were suffering from non-WD(N-WD)and 37 were heterozygous ATP7B carriers(HC)enrolled as controls.Molecular genetic testing was performed for diagnosing WD and HC.Additionally,REC levels in different TCM syndromes were investigated.The correlation between REC and serum ceruloplasmin(Cp),serum copper oxidase(CO),and 24-h urinary copper was analyzed using the Global Assessment Scale and Unified Wilson's Disease Rating Scale and the significance of REC in WD diagnosis was investigated.Resting-state functional magnetic resonance imaging was used to assess the clinical symptoms of WD and analyze its severity in different TCM syndromes.RESULTS:REC determination helped in significantly distinguishing patients with N-WD or HC from those with WD with a cut-off of 21.15％.Furthermore,the comparative analysis of REC ratios among different TCM syndromes showed markedly high REC levels in the dampness-heat internal accumulation syndrome group.Additionally,the seed-based functional connectivity value from the putamen to the cerebellum was significantly correlated with TCM syndromes.CONCLUSION:REC level is a high-quality biomarker for diagnosing WD that effectively reflects disease severity and plays an essential role in deciding on treatment strategies and prognosis.Furthermore,REC levels are closely related to TCM syndromes in WD;thus,it is a potential objective quantitative indicator for distinguishing TCM syndromes in WD.

外文关键词：

Wilson's diseaserelative exchangeable copperTraditional Chinese Medicine syndromeGlobal Assessment Scalethe Unified Wilson's Disease Rating Scale

作者：

DING Yufeng、YANG Wenming、CHENG Yuan、YANG Yulong、ZHU Jun、LU Yachun、FANG Xiang、ZHANG Jing

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作者单位：

Department of Neurology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China

Department of clinical laboratory,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China

关键词：

Wilson's disease relative exchangeable copper Traditional Chinese Medicine syndrome Global Assessment Scale the Unified Wilson's Disease Rating Scale

出版年：

2024

DOI：

10.19852/j.cnki.jtcm.20240828.007

中医杂志(英文版)

中国中医药学会中国中医研究院

中医杂志(英文版)

影响因子：0.855

ISSN：0255-2922

年,卷(期)：2024.44(5)