首页|Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type
Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type
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OBJECTIVE:To compare the efficacy and safety of different Traditional Chinese Medicine(TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis(RA).METHODS:The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA.Eight electronic databases and two trial registration platforms were searched.RevMan 5.4 and Stata 16 software were employed.RESULTS:A total of 42 studies involving 3779 cases were included.The results showed that the most effective intervention for improving efficacy was Wanbi decoction(顽痹汤);Bushen Quhan Zhiwang decoction(补肾祛寒治尪汤)was superior in reducing the incidence of adverse reactions;and Qiwei Tongbi oral liquid(七味通痹口服液)effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.CONCLUSION:Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments,reduce inflammatory indexes,and result in a higher safety profile.However,this conclusion needs to be verified by more high-quality randomized controlled trials.
arthritis,rheumatoidMedicine,Chinese Traditionaltonifying kidney and strengthening bonesnetwork Meta-analysis
GAN Chang、TAO Qingwen、YI Haoying、BIAN Yuting、WANG Jianming
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School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China
Department of Traditional Chinese Medicine Rheumatology,China-Japan Friendship Hospital,Beijing 100029,China
Beijing Key Lab for Immune-Mediated Inflammatory Diseases,China-Japan Friendship Hospital,Beijing 100029,China
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