"异类相制"理论及其指导下的有毒中药应用策略
Application Strategy of Toxic Chinese Materia Medica Based on the Theory of "Heterogeneous Medicinals Mutual Restriction"
周学平 1冯哲 1俞志超 2聂炜珏1
作者信息
- 1. 南京中医药大学第一临床医学院,江苏省南京市栖霞区仙林大道138号,210023
- 2. 南京中医药大学中医学院
- 折叠
摘要
有毒中药功专效捷,其安全应用已成为临床亟待解决的难题,而配伍减毒是有毒中药临床合理应用、发挥其疗效优势的重要方法."异类相制"理论形成于长期的临床实践认知,是临床经验的提炼升华,其含义为有毒中药通过与不同性味、不同功效中药的合理配伍,以调其偏性、制其毒性."异类相制"理论涵盖了性味相制、异效相制、扶正制毒的配伍减毒方式及交互相呈关系,各药物配伍所起的相反相成作用是其内涵的延伸,可从物质基础、效应机制两方面阐释其原理.在此理论指导下,能够优化有毒中药复方配伍方法,为临床有毒中药的配伍组方提供新策略,实现复方的减毒增效.
Abstract
Toxic Chinese materia medica has been highly valued by its specialized and effective effects,but its safe application has become an urgent clinical problem to be solved.Compatibility for toxic attenuation is an important method for the rational clinical application of toxic Chinese materia medica as well as the promotion of its therapeutic advantages.The theory of "heterogeneous medicinals mutual restriction" elaborated in this article has been formed through long-term clinical practice and cognition,and refinement of clinical experience,which means that the nature partiality of toxic Chinese materia medica can be adjusted,and the toxicity can be suppressed through reasonable com-bination with herbal medicinalsof different properties,flavors,and effects.This theory covers the modes of compati-bility for toxicity attenuation and the interaction relationships,like the restriction of medicinals with different properties and flavors,restriction of medicinals with different effects,and inhibiting toxins by reinforcing healthy qi.The oppo-site and complementary effects of various medicinals combinations are an extension of the connotations of this theory,and the principles can be explained from material basis and mechanism of action.Under the guidance of this theory,it is possible to optimize the compound prescription strategies of toxic Chinese materia medica,and provide new strategies for the clinical combinations of toxic Chinese materia medica,thereby achieving the reduction of toxicity and enhance-ment of effectiveness of the compound formulas.
关键词
异类相制/有毒中药/配伍减毒/组方策略Key words
heterogeneous medicinals mutual control/toxic Chinese materia medica/compatibility for toxicity attenua-tion/strategy of prescription引用本文复制引用
基金项目
国家自然科学基金(81973741)
国家自然科学基金(82374187)
江苏省高等学校基础科学研究项目(23KJB360012)
出版年
2024
国家科技期刊平台
NSTL
万方数据