Objective To observe the effectivenss and safety of Yiqi Huoxue Formula(益气活血方)combined with surgery and sequential therapy of estrogen and progesterone for the treatment of intrauterine adhesion(IUA)with syndrome of qi deficiency and blood stasis.Methods Sixty-four patients with IUA were recruited in Guang'anmen Hospital,China Academy of Chinese Medical Sciences during 1st June 2021 to 31st December 2022,and they were randomly divided into two groups,with 32 patients in each group,all receiving transcervical resection of adhesions(TCRA).The control group was treated with sequential therapy of estrogen and progesterone after surgery,taking 1 tablet orally daily,estradiol tablets for the first 14 days,and estradiol dydrogesterone tablets for the last 14 days.In the treatment group,the postoperative treatment was combined with Yiqi Huoxue Formula on the basis of the treatment in the control group,and 1 dose was taken daily.The treatment course of both groups was 3 months.We observed the clinical effectiveness,syndrome scores of traditional Chinese Medicine(TCM),endometrial thickness,uterine adhe-sion score,menstrual flow points,and the re-adhesion rate and pregnancy rate 3 months after the end of treatment of the two groups,and conducted evaluation on safety.Results The total clinical effective rates of the treatment group and the control group were 90.63％ and 75.00％,respectively,significantly better in the treatment group(P＜0.05).The endometrial thickness and menstrual flow of patients in both groups increased after treatment,and the scores of uterine adhesion and TCM syndrome scores decreased significantly(P＜0.05 or P＜0.01).After treat-ment,the uterine adhesion score and TCM syndrome scores of the treatment group decreased significantly compared with the control group(P＜0.05).The 6-month postoperative pregnancy rate in the treatment group was 37.50％,higher than the 12.50％ in the control group(P＜0.05).The re-adhesion rate was 3.13％ in the treatment group and 9.38％ in the control group,and the difference between groups was not statistically significant(P＞0.05).No adverse events occurred in both groups.Conclusion Yiqi Huoxue Formula combined with surgery and sequential therapy of estrogen and progesterone for treating IUA patients with syndrome of qi deficiency and blood stasis can promote endo-metrial recovery,increase menstrual flow,improve patients'clinical symptoms,and improve pregnancy rate,showing certain clinical effectiveness and safety.
intrauterine adhesiontranscervical resection of adhesionsYiqi Huoxue Formula(益气活血方)estrogenprogesteronepregnancy rateendometrium
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