ABSTRACT To summarize Professor TU Jinwen's clinical experience in the treatment of severe influenza based on the theory of"heat toxin".It is believed that"heat toxin"is the main mechanism of severe influenza,emphasized the pathogenesis process that toxin enters with the pathogenic qi,heat generates by the toxin,and changes initiate from the toxin,and proposed simultaneous treatment of warmth and toxin,and combination of multiple methods as the treat-ment principles.Syndrome differentiation in clinic should combine with wei-qi-ying-blood.The disease in the early stage located in wei(defensive)and qi level,treated by clearing heat and resolving toxins,releasing the exterior and expel-ling pathogen,harmonizing the exterior and interior,dredging the bowels with diarrhea,and combining other methods to get rid of the heat and toxin,and modified Self-Prescribed Tuire No.1 Formula(退热 1号方)is recommended;the disease in progression stage located in ying-blood,treated by relieving heat and resolving toxins,and clearing the ying level and cooling the blood,with prescriptions as modified Self-Prescribed Tuire No.1 Formula plus Qingying Decoction(清营汤),or Xijiao Dihuang Decoction(犀角地黄汤);the disease in the late stage with of yin fluid consump-tion,and heat toxin in the blood level,treated by eliminating heat and resolving toxins,and enriching yin and cooling the blood,with prescriptions as modified Shashen Maidong Decoction(沙参麦冬汤)and Zhuye Shigao Decoction(竹叶石膏汤).At the same time,it is emphasised that heat-clearing and fire-draining method and harmonising methods are important,and that dispelling pathogen should not injure healthy qi,and that the selection of prescriptions and medicines need consider syndrome differentiation and treatment.
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