Objective To construct traditional Chinese medicine(TCM)diagnostic scale of turbid toxin syn-drome in order to provide corresponding reference for the standardization of TCM syndromes and studies.Methods We systematically searched the Chinese Medical Dictionary(CMD),China Knowledge Network(CNKI),Wanfang Data Knowledge Service Platform(WF)and VIP database for TCM classics and modern literature on turbid toxin syn-drome,and initially screened the four diagnosis information of turbid toxin syndrome,established a pool of informa-tion entries,and conducted a cross-sectional clinical survey.Discrete trend method,correlation coefficient method,Cronbach's coefficient method,and factor analysis method were applied to objectively screen the entries.The diagnos-tic scale of turbid toxin syndrome were constructed through three rounds of Delphi method expert survey to determine the scale entries,using hierarchical analysis to get the judgement matrix scores and relative weight of each entry,after passing consistency test and then isometric expansion of the relative weight of the entries to get the weight of each en-try and assign the value.Results A total of 35 articles were included,45 entries were obtained after the initial screening.After the clinical investigation,12 entries were not suitable by the discrete trend method,23 entries not suitable by correlation coefficient method,13 entries by the internal consistency screening were removed with the Cronbach's alpha coefficient rising,and 10 entries not suitable by the factor analysis method.Twenty-two entries were retained after objective screening by the combined use of the four statistical methods.The positive coefficients of experts in the three rounds of Delphi method of expert consultation were 96.67％,the coefficients of expert authority were 0.834,0.856,and 0.867,and the coefficients of co-ordination were 0.126,0.326,and 0.312,respectively.After consulting with clinical experts,and three rounds of Delphi method survey and hierarchical analysis method weight assignment,the diagnostic scale entries of turbid toxin syndrome were finally established.Primary symp-toms:dark red or purple and dusky tongue,yellowish greasy or dry coating(10 points);sticky and unpleasant stools(8 points);disharmony of tastes including halitosis,sticky and greasy taste in the mouth,dry mouth and bitter taste in the mouth(6 points);unfavourable or yellowish or red urination(5 points);and dark complexion(4 points).Secondary symptoms:heavy body(3 points);dizziness(3 points);profuse,sticky,foul-smelling secretions(2 points);wiry and slippery,or slippery,or slippery and rapid pulse(2 points);feeling of hardness in the abdomen(1 point).Conclusion Using Delphi method combined with the hierarchical analysis method,combining qualita-tive and quantitative study,a diagnostic scale of turbid toxin syndrome was initially developed.
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