Chinese Herbal Enema Combined with Fumigation as Adjunctive Therapy for 60 Cases of Non-dialysis Chronic Kidney Disease Patients of Stage 3-5 with Spleen-kidney Yang Deficiency and Turbid Toxin Blood Stasis Pattern:A Randomized Controlled Trial
Objective To observe the clinical efficacy and safety of Chinese herbal enema combined with fumi-gation as adjunctive therapy for non-dialysis chronic kidney disease(CKD)patients of stage 3-5 with spleen-kidney yang deficiency and turbid toxin blood stasis pattern.Methods A total of 120 non-dialysis CKD,patients of stage 3-5 with spleen-kidney yang deficiency and turbid toxin blood stasis pattern were randomly divided into treatment group and control group,with 60 cases in each group.The control group received conventional western medical treat-ment,while the treatment group additionally received Chinese herbal enema combined with fumigation,with enema and fumigation performed alternately,once every other day,three times a week.The treatment course for both groups was 4 weeks.The levels of serum creatinine(Scr),estimated glomerular filtration rate(eGFR),and the total score of traditional Chinese medicine symptoms were compared before and after treatment in both groups.The efficacy of tradi-tional Chinese medicine symptoms and clinical efficacy were compared between the two groups after treatment.Adverse reactions in both groups were observed during the treatment period.Results The total score of traditional Chinese medicine symptoms was significantly reduced after treatment in both groups(P＜0.01).Compared to the control group after treatment,the treatment group showed significant decreases in Scr and the total score of traditional Chinese medicine symptoms,and a significant increase in eGFR(P＜0.05).The total effective rate of traditional Chinese medicine symptoms in the treatment group(96.67％)was higher than that in the control group(46.67％,P＜0.01),as well as the total effective rate of clinical efficacy in the treatment group(75.00％)versus that in the control group(28.33％,P＜0.01).During the treatment period,the vital signs of patients in both groups remained stable,and there were no significant abnormalities in blood routine,urine routine,stool routine,liver function indica-tors,and electrocardiogram after treatment.Conclusion Chinese herbal enema combined with fumigation as adjunc-tive therapy can significantly alleviate clinical symptoms,improve renal function,and demonstrate good safety for non-dialysis CKD patients of stage 3-5 with spleen-kidney yang deficiency and turbid toxin blood stasis pattern.
NETL
NSTL
维普
万方数据
