摘要
将"稳态"应用于经络系统的研究,提出经络系统保持平衡、平稳的状态为经络稳态.经络稳态对维持机体健康具有重要作用,可为疾病的诊断和治疗提供参考.表型组学实现了从基因组、蛋白组、代谢组等微观表型数据到生理状态、行为活动、外在表现等宏观表型数据的跨尺度关联.从表型组学的研究角度出发,提出"宏观征象-微观表达"的经络稳态动态映射模型,将中医四诊等宏观征象、穴位的生物物理指标以及基因、蛋白和代谢等微观表达信息结合,系统性地探究经络稳态与健康和疾病的关系,为中医未病状态识别以及精准化诊疗提供思路和参考.
Abstract
By applying"homeostasis"to the study of the meridian and collateral system,the concept of meridian and collateral homeostasis has been proposed which refers to a balanced and stable state of meridian and collateral system,and plays an important role in maintaining body health and can provide a reference for the diagnosis and treat-ment of diseases.Phenomics realizes the cross-scale correlation from micro-phenotypic data,such as genome,proteome,and metabolome,to macro-phenotypic data,such as physiological state,behavioral activities,and external manifestations.From the perspective of phenomics,this paper proposes a meridian and collateral homeostasis dynamic mapping model of"macroscopic signs and microscopic expression".This model combines macro signs such as the four examinations of traditional Chinese medicine(TCM),biophysical indicators of acupoints,and micro expression infor-mation such as genes,proteins,and metabolism,and systematically investigates the relationship between meridian and collateral homeostasis and health and disease,thereby providing ideas and references for the identification of pre-disease states as well as precise diagnosis and treatment in TCM.
基金项目
国家中医药局中医药创新团队及人才支持计划(ZYYCXTD-D-202003)
四川省科技厅科技项目(22ZDYE2456)
国家科技期刊平台
NSTL
万方数据