Study on the Prevalence Difference between Northwest Dryness Syndrome and Blood Stasis Syndrome of Coronary Heart Disease and the Correlation with Major Adverse Cardiovascular Events
Objective To explore the prevalence difference between northwest dryness syndrome and blood stasis syndrome of coronary heart disease(CAD)and their correlations with major adverse cardiovascular events(MACE).Methods The medical records including general information and risk factors for vascular diseases(gender,age,smoking history,diabetes history,hypertension history,chronic kidney disease history and body mass index),laboratory indicators(fasting blood glucose,triglyceride,high density lipoprotein cholesterol,etc.)of 499 CAD patients in the Department of Cardiology of the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from November 1st,2015 to September 30th,2020 were collected,and whether they suffered from northwest dryness syn-drome or blood stasis syndrome was judged.The incidence of MACE was followed up for one year.The differences of cardiovascular risk factors between the northwest dryness syndrome and blood stasis syndrome of CAD were com-pared,and the correlation with MACE was analyzed.Results Among the 499 CAD patients,there were 128 cases(25.65％)of simple blood stasis syndrome,33 cases(6.61％)of simple northwest dryness syndrome,209 cases(41.88％)of northwest dryness syndrome plus blood stasis syndrome,and 129(25.85％)cases of not blood statis syndrom either northwest dryness syndrome.Univariate regression analysis showed that smoking history,diabetes his-tory,fasting blood glucose abnormality,triglyceride abnormality,and high density lipoprotein cholesterol abnormality were positively correlated with northwest dryness syndrome in CAD patients(OR＞1,P＜0.05),while smoking his-tory,abnormal triglyceride and abnormal high density lipoprotein cholesterol were positively correlated with blood stasis syndrome in CAD patients(OR＞1,P＜0.05).Multivariate regression analysis showed that the history of diabetes,abnormal triglyceride and abnormal high density lipoprotein cholesterol were positively correlated with northwest dry-ness syndrome of CAD(P＜0.05).Smoking history,abnormal triglycerides and abnormal high density lipoprotein cholesterol were positively correlated with blood stasis syndrome(P＜0.05).Association rule analysis showed that the confidence of CAD patients with northwest dryness syndrome complicated with blood stasis syndrome was 86.36％,and that of patients with blood stasis syndrome complicated with northwest dryness syndrome was 62.02％.Among the 499 patients,96 had MACE in one year,accounting for 19.24％of the total.Logistics regression analysis showed that the correlation with incidence of MACE in CAD patients within one year from strong to weak was northwest dryness syndrome plus blood stasis syndrome[OR=5.113,95％CI(3.118,8.387),P＜0.001)],blood stasis syn-drome[OR=4.630,95％CI(2.394,8.955),P＜0.001],northwest dryness syndrome[OR=4.395,95％CI(2.642,7.309),P＜0.001].Conclusion Blood stasis syndrome is the main syndrome type of CAD in Xinjiang Uygur Autonomous Region.CAD patients with northwest dryness syndrome are more likely to have blood stasis syn-drome,and most suffer from both northwest dryness syndrome and blood stasis syndrome simultaneously.There is the strongest correlation between northwest dryness syndrome plus blood stasis syndrome and 1-year occurrence of MACE in CAD.
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