中医杂志2024,Vol.65Issue(16) :1721-1724.DOI:10.13288/j.11-2166/r.2024.16.016

系统性红斑狼疮的伏毒病机演变及辨治

Mechanism Evolution of Latent Toxin in Systemic Lupus Erythematosus and Syndrome Differentiation and Treatment

张祎 谢志军 黄琳 王俏 李海昌 温成平
中医杂志2024,Vol.65Issue(16) :1721-1724.DOI:10.13288/j.11-2166/r.2024.16.016

系统性红斑狼疮的伏毒病机演变及辨治

Mechanism Evolution of Latent Toxin in Systemic Lupus Erythematosus and Syndrome Differentiation and Treatment

张祎 1谢志军 1黄琳 1王俏 1李海昌 1温成平1
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作者信息

  • 1. 浙江中医药大学,浙江省杭州市滨江区滨文路548号,310053
  • 折叠

摘要

提出系统性红斑狼疮(SLE)的病机演变可以概括为四个阶段:邪伏初期,病机潜伏;伏毒积聚,病情渐显;邪毒致损,病势凶猛;因损致虚,病程迁延.根据伏毒病机演变过程对SLE进行辨治:邪伏阶段表现为伏湿郁热,方用三仁汤加减;毒发阶段表现为热毒炽盛,方用犀角地黄汤合清瘟败毒饮加减;毒损阶段表现为毒损脏腑,方用青蒿鳖甲汤加减;正虚阶段表现为气血阴阳俱虚,方用燮理十全膏加减.

Abstract

It is proposed that the disease mechanism evolution of systemic lupus erythematosus can be summa-rized into four stages:initial invasion and latency,the pathogenesis remains concealing;latent toxin accumulation,the disease gradually becomes apparent;active toxin begins damaging,the disease manifests aggressively;damage re-sulting to deficiency,the disease course prolonged.Based on the stages of latent toxin evolution,the syndrome differ-entiation and treatment of systemic lupus erythematosus can be summarized as follows:during the initial latent stage,characterized by latent dampness and heat stagnation,modified Sanren Decoction(三仁汤)should be used;in the toxin outbreak stage,marked by intense heat toxin,modified Xijiao Dihuang Decoction(犀角地黄汤)combined with modi-fied Qingwen Baidu Decoction(清瘟败毒饮)should be used;during the toxin damage stage,which presents as latent toxin damaging zang-fu organs,modified Qinghao Biejia Decoction(青蒿鳖甲汤)should be used;in the healthy qi de-ficiency stage,characterized by deficiencies of qi,blood,yin,and yang,modified Xieli Shiquan Ointment(燮理十全膏)should be used.

关键词

系统性红斑狼疮/阴阳毒/伏毒/病机演变

Key words

systemic lupus erythematosus/yin-yang toxin/latent toxin/evolution of disease mechanism

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基金项目

国家自然科学基金(U21A20402)

国家自然科学基金(82374395)

国家自然科学基金(81973829)

出版年

2024
中医杂志
中华中医药学会 中国中医科学院

中医杂志

CSTPCD北大核心
影响因子:1.464
ISSN:1001-1668
参考文献量14
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