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系统性红斑狼疮的伏毒病机演变及辨治

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提出系统性红斑狼疮(SLE)的病机演变可以概括为四个阶段:邪伏初期,病机潜伏;伏毒积聚,病情渐显;邪毒致损,病势凶猛;因损致虚,病程迁延.根据伏毒病机演变过程对SLE进行辨治:邪伏阶段表现为伏湿郁热,方用三仁汤加减;毒发阶段表现为热毒炽盛,方用犀角地黄汤合清瘟败毒饮加减;毒损阶段表现为毒损脏腑,方用青蒿鳖甲汤加减;正虚阶段表现为气血阴阳俱虚,方用燮理十全膏加减.
Mechanism Evolution of Latent Toxin in Systemic Lupus Erythematosus and Syndrome Differentiation and Treatment
It is proposed that the disease mechanism evolution of systemic lupus erythematosus can be summa-rized into four stages:initial invasion and latency,the pathogenesis remains concealing;latent toxin accumulation,the disease gradually becomes apparent;active toxin begins damaging,the disease manifests aggressively;damage re-sulting to deficiency,the disease course prolonged.Based on the stages of latent toxin evolution,the syndrome differ-entiation and treatment of systemic lupus erythematosus can be summarized as follows:during the initial latent stage,characterized by latent dampness and heat stagnation,modified Sanren Decoction(三仁汤)should be used;in the toxin outbreak stage,marked by intense heat toxin,modified Xijiao Dihuang Decoction(犀角地黄汤)combined with modi-fied Qingwen Baidu Decoction(清瘟败毒饮)should be used;during the toxin damage stage,which presents as latent toxin damaging zang-fu organs,modified Qinghao Biejia Decoction(青蒿鳖甲汤)should be used;in the healthy qi de-ficiency stage,characterized by deficiencies of qi,blood,yin,and yang,modified Xieli Shiquan Ointment(燮理十全膏)should be used.

systemic lupus erythematosusyin-yang toxinlatent toxinevolution of disease mechanism

张祎、谢志军、黄琳、王俏、李海昌、温成平

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浙江中医药大学,浙江省杭州市滨江区滨文路548号,310053

系统性红斑狼疮 阴阳毒 伏毒 病机演变

国家自然科学基金国家自然科学基金国家自然科学基金

U21A204028237439581973829

2024

中医杂志
中华中医药学会 中国中医科学院

中医杂志

CSTPCD北大核心
影响因子:1.464
ISSN:1001-1668
年,卷(期):2024.65(16)