中医杂志2024,Vol.65Issue(19) :1988-1993.DOI:10.13288/j.11-2166/r.2024.19.007

基于"五观辨治"体系论治胃"炎-癌"转化

Discussion on Treatment of Gastric"Inflammation-cancer"Transformation based on the"Five-view Differentiation and Treatment"System

葛媛莎 许博文 李杰
中医杂志2024,Vol.65Issue(19) :1988-1993.DOI:10.13288/j.11-2166/r.2024.19.007

基于"五观辨治"体系论治胃"炎-癌"转化

Discussion on Treatment of Gastric"Inflammation-cancer"Transformation based on the"Five-view Differentiation and Treatment"System

葛媛莎 1许博文 1李杰2
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作者信息

  • 1. 中国中医科学院广安门医院,北京市西城区北线阁5号,100053;北京中医药大学
  • 2. 中国中医科学院广安门医院,北京市西城区北线阁5号,100053
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摘要

规范化胃镜筛查使胃癌前病变(PLGC)的诊断更加明确,Correa演变是胃炎-癌转化的关键,提示PLGC是机体由正常转向癌变的核心.基于恶性肿瘤"五观辨治"体系中未病观、时空观、核心观、症状观、精准观五个维度探索建立防治良性、炎性病变恶性转化的新体系,即:1)未病观:尽早干预截断炎-癌转化.2)时空观:遵循疾病进展时空构架.3)核心观:挈领炎-癌转化核心病机.在分期方面,早期气虚郁滞,治以益气解郁,中期阴浊内壅,治以温阳化浊,癌变期癌毒瘀阻,治以抗癌解毒化瘀;在病位方面,上部者理气化痰、引而越之,中部者养阴清热、泻之于内,下部者行气散寒、引而竭之.4)症状观:活用药对解决主要症状;5)精准观:富集靶标定向防控癌变.

Abstract

Standardized gastroscopy screening makes the diagnosis of precancerous lesions of gastric cancer(PLGC)clearer.Correa evolution is the key to gastritis-cancer transformation,suggesting that PLGC is the core of the body's transformation from normal to cancer.Based on the"five-view differentiation and treatment"system for malig-nant tumors,we explored the establishment of a new system for preventing and treating malignant transformation of benign and inflammatory lesions from five dimensions,including pre-disease view,time-space view,core view,symp-toms view and precision view.(a)pre-disease view:early intervention to intercept inflammation-cancer transforma-tion;(b)time-space view:following the time-space framework as the disease progresses;(c)core view:focusing on the core pathogenesis of inflammation-cancer transformation.In terms of different stages,qi deficiency and stagnation are mainly manifested in the early stage,which can be treated by invigorating qi and resolving constraint;in the middle stage,yin turbidity is blocked internally,and it can be treated by warming yang and removing turbidity;in the cancerous stage,cancer toxin are blocked,for which the anti-cancer,toxins-resolving and stasis-dissolving method is suggested.In terms of the location of the disease,it is suggested to relieve disease in the upper body by rectifying qi and dissolving phlegm with emetic therapy(vomit induction);for the disease in the middle,it it suggested to nourish yin and clear heat by elimination method;pathogen in the lower requires dredging method by moving qi and dissipat-ing cold;(d)symptoms view:using herbal pairs to deal with the main symptoms;(e)precision view:enriching targets to prevent and control cancer directionally.

关键词

胃癌前病变/炎-癌转化/Correa演变

Key words

precancerous lesions of gastric cancer/inflammation-cancer transformation/Correa evolution

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基金项目

中国中医科学院科技创新工程重大攻关项目(CI2021A01802)

北京市重大疑难疾病中西医协同攻关项目(2023BJSZDYNJBXTGG-013)

中央高水平中医医院临床研究和成果转化能力提升项目-临床科研一体化人才专项(创新团队培育项目)(HLCMHPP2023001)

中央高水平中医医院临床研究和成果转化能力提升项目-临床科研一体化人才专项(领军人才培育项目)(HLCMHPP2023097)

出版年

2024
中医杂志
中华中医药学会 中国中医科学院

中医杂志

CSTPCDCSCD北大核心
影响因子:1.464
ISSN:1001-1668
参考文献量60
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