首页|基于肾虚精亏理论探讨类风湿关节炎骨破坏的发生发展机制

基于肾虚精亏理论探讨类风湿关节炎骨破坏的发生发展机制

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类风湿关节炎以持续性滑膜炎、血管翳的形成为特征性病理改变,晚期可出现不可逆的骨关节破坏和变形.提出肾虚精亏为类风湿关节炎骨破坏的核心病机,其疾病演变为"髓减、肉痿、络阻",并据此梳理类风湿关节炎骨破坏的现代医学认识,认为"髓减、肉痿、络阻"终使骨破坏的中医病机与破骨细胞异常分化、核因子-κB受体活化因子配体的高表达及炎症因子异常分泌的西医机制有相通之处,可为全面且科学地阐释类风湿关节炎骨破坏的病理机制提供参考.
Mechanism of Bone Destruction in Rheumatoid Arthritis Based on the Theory of Kidney Deficiency and Essence Deficiency
Rheumatoid arthritis is a common clinical autoimmune disease characterized by persistent synovitis and pannus formation.In late stage,irreversible destruction and deformation of bone and joint may occur.In this paper,the authors believe that kidney deficiency and essence deficiency is the core mechanism of rheumatoid arthritis bone destruction,and its disease evolution law is summarized as"marrow reduction,flesh flaccid,collaterals blocked".On the basis of modern medical understanding of bone destruction in rheumatoid arthritis,it is considered that the mechanism in Chinese medicine of"marrow reduction,flesh flaccid,collaterals blocked"ultimately leads to bone destruction,is similar to that in the western medicine of abnormal differentiation of osteoclasts,high expression of nuclear factor-κB receptor activator of ligand,and abnormal expression of inflammatory factors.This point of view may provide a more comprehensive and scientific understanding of the key pathogenic mechanism of bone destruction in rheumatoid arthritis.

rheumatoid arthritisbone destructionkidney deficiency and essence deficiencybones withering and marrow reducingimbalance of muscles and bonesphlegm-dampness stasis obstruction

朱文菊、苏小军、何倩、王欢、张志明、沈海丽、叶孝涛

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甘肃中医药大学,甘肃省兰州市城关区定西东路35号,730030

甘肃省中医院

兰州大学第二医院

类风湿关节炎 骨破坏 肾虚精亏 骨枯髓减 肌骨失衡 痰湿瘀阻

国家自然科学基金甘肃省自然科学基金甘肃省中医药管理局重点科研项目

8226088022JR5RA626GZKZ-2021-3

2024

10.13288/j.11-2166/r.2024.19.015

中医杂志
中华中医药学会 中国中医科学院

中医杂志

CSTPCD北大核心
影响因子：1.464
ISSN：1001-1668
年,卷(期)：2024.65(19)