Rheumatoid arthritis is a common clinical autoimmune disease characterized by persistent synovitis and pannus formation.In late stage,irreversible destruction and deformation of bone and joint may occur.In this paper,the authors believe that kidney deficiency and essence deficiency is the core mechanism of rheumatoid arthritis bone destruction,and its disease evolution law is summarized as"marrow reduction,flesh flaccid,collaterals blocked".On the basis of modern medical understanding of bone destruction in rheumatoid arthritis,it is considered that the mechanism in Chinese medicine of"marrow reduction,flesh flaccid,collaterals blocked"ultimately leads to bone destruction,is similar to that in the western medicine of abnormal differentiation of osteoclasts,high expression of nuclear factor-κB receptor activator of ligand,and abnormal expression of inflammatory factors.This point of view may provide a more comprehensive and scientific understanding of the key pathogenic mechanism of bone destruction in rheumatoid arthritis.
关键词
类风湿关节炎/骨破坏/肾虚精亏/骨枯髓减/肌骨失衡/痰湿瘀阻
Key words
rheumatoid arthritis/bone destruction/kidney deficiency and essence deficiency/bones withering and marrow reducing/imbalance of muscles and bones/phlegm-dampness stasis obstruction
维普
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