Circadian rhythm disorders are closely related to metabolic diseases,which can cause non-alcoholic fatty liver disease(NAFLD)by directly acting on the liver or indirectly affecting the liver through the liver-brain axis and intestinal flora.The rhythms of yin and yang,ying(营)and wei(卫),twelve hours and four seasons in traditional Chinese medicine(TCM)chronomedicine are similar to the connotations of modern biological rhythms.From the per-spective of chronomedicine of TCM,the incidence of NAFLD is closely related to the abnormality of the daily rhythm of the waxing and waning of yin and yang,the daily rhythm of the circulation of ying and wei,the rhythm of twelve hours and four seasons.Through analyzing the rhythms related to the occurrence,development and prognosis of NAFLD,it is helpful to enhance the understanding of NAFLD in relation to time,so as to better guide the clinical diagnosis and treatment.
关键词
非酒精性脂肪性肝病/中医时间医学/昼夜节律/肝-脑轴/肠道菌群
Key words
non-alcoholic fatty liver disease/traditional Chinese medicine chronomedicine/circadian rhythm disor-ders/liver-brain axis/intestinal flora