Circadian rhythm disorders are closely related to metabolic diseases,which can cause non-alcoholic fatty liver disease(NAFLD)by directly acting on the liver or indirectly affecting the liver through the liver-brain axis and intestinal flora.The rhythms of yin and yang,ying(营)and wei(卫),twelve hours and four seasons in traditional Chinese medicine(TCM)chronomedicine are similar to the connotations of modern biological rhythms.From the per-spective of chronomedicine of TCM,the incidence of NAFLD is closely related to the abnormality of the daily rhythm of the waxing and waning of yin and yang,the daily rhythm of the circulation of ying and wei,the rhythm of twelve hours and four seasons.Through analyzing the rhythms related to the occurrence,development and prognosis of NAFLD,it is helpful to enhance the understanding of NAFLD in relation to time,so as to better guide the clinical diagnosis and treatment.
non-alcoholic fatty liver diseasetraditional Chinese medicine chronomedicinecircadian rhythm disor-dersliver-brain axisintestinal flora
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