This article is to illustrate the connection between neutrophil extracellular traps(NETs)and stasis-toxin interactions during the development of liver cancer,and to provide ideas for the prevention and treatment of liver cancer.It is believed that the mechanism of tumor-related thrombosis formation caused by NETs is closely related to"stasis"in traditional Chinese medicine(TCM),and the continuous maintenance or enhancement of tumor microenvi-ronment by NETs is closely related to"toxin"in TCM;the strong coagulation-promoting effect of NETs makes the lo-cal microenvironment,which can be regarded as the toxin caused by blood stasis;the changes of tumor microenviron-ment induced by NETs further induced platelet aggregation,which may present a state of stasis caused by toxin;the pathological changes of liver cancer caused by NETs can be regarded as the microscopic manifestation of the mecha-nism of stasis-toxin interaction of liver cancer.
liver cancerstasis and toxin interactionneutrophil extracellular trapsdisease mechanism
NETL
NSTL
万方数据
