基于中性粒细胞胞外诱捕网论肝癌瘀毒互结病机的科学内涵
Discussion on the Scientific Connotation of Disease Mechanism of Stasis and Toxin Interaction of Liver Cancer based on Neutrophil Extracellular Traps
强睿 1李爽 1吕文良 2杨国旺3
作者信息
- 1. 北京中医医院顺义医院,北京市顺义区健盛街1号院,101300
- 2. 中国中医科学院广安门医院
- 3. 首都医科大学附属北京中医医院
- 折叠
摘要
阐释肝癌发生发展过程中中性粒细胞胞外诱捕网(NETs)与瘀毒互结病机的联系,为肝癌的防治提供思路.认为NETs致肝癌相关血栓形成的机制与中医学"瘀"形成的过程具有相似性,NETs维持或增强肿瘤微环境的机制亦与中医学"毒"形成的过程具有相似性;NETs的促凝作用促使局部形成肿瘤微环境可视为因瘀致毒状态,而NETs致肿瘤微环境变化可进一步诱导血小板聚集呈现出因毒致瘀状态;NETs导致肝癌发生发展的病理变化可视作肝癌瘀毒互结病机的微观表现.
Abstract
This article is to illustrate the connection between neutrophil extracellular traps(NETs)and stasis-toxin interactions during the development of liver cancer,and to provide ideas for the prevention and treatment of liver cancer.It is believed that the mechanism of tumor-related thrombosis formation caused by NETs is closely related to"stasis"in traditional Chinese medicine(TCM),and the continuous maintenance or enhancement of tumor microenvi-ronment by NETs is closely related to"toxin"in TCM;the strong coagulation-promoting effect of NETs makes the lo-cal microenvironment,which can be regarded as the toxin caused by blood stasis;the changes of tumor microenviron-ment induced by NETs further induced platelet aggregation,which may present a state of stasis caused by toxin;the pathological changes of liver cancer caused by NETs can be regarded as the microscopic manifestation of the mecha-nism of stasis-toxin interaction of liver cancer.
关键词
肝癌/瘀毒互结/中性粒细胞胞外诱捕网/病机Key words
liver cancer/stasis and toxin interaction/neutrophil extracellular traps/disease mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
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