Application of Matching-adjusted Indirect Comparison Methods in Efficacy Evaluation of Traditional Chinese Medicine
Randomized controlled trials(RCTs)have been widely used in clinical efficacy evaluation of tradi-tional Chinese medicine(TCM),but also having limitations such as high cost,time consuming,and difficulty in patient recruitment and enrollment.The introduction of matching adjusted indirect comparison(MAIC)can alleviate the problem caused by the limitation of traditional RCT methodology to some extent.This paper introduced the basic principles of MAIC,and analyzed the similarities and differences,advantages and disadvantages of the two design methods,that is the anchored and the non-anchored.By analyzing two case studies in the evaluation of TCM efficacy,which are acupuncture for paroxysmal migraine and moxibustion for diarrhea-type irritable bowel syndrome,respec-tively,this paper introduced the methodological characteristics of MAIC in the efficacy evaluation of TCM,explored the strengths and feasibility of MAIC in the evaluation of efficacy evidence in TCM,the evaluation of efficacy of non-pharmacological TCM therapy and the development of new Chinese medicine,and discussed the limitations of existing research,matching factors and sample size.Additionally,the paper offered prospects by combining the simulation treatment comparison method and emulated target trials,with the goal of providing recommendations and references for the clinical efficacy evaluation of TCM.
efficacy evaluation of traditional Chinese medicinematching adjustmentindirect comparisonrando-mized controlled trials
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