Observation on the Effect of Buzhong Yiqi Decoction(补中益气汤)in the Treatment of 36 Mechanically Ventilated Cases of ICU-acquired Weakness with Spleen Qi Deficiency Syndrome
Objective To analyze the efficacy and safety of Buzhong Yiqi Decoction(补中益气汤,BYD)in the treatment of mechanically ventilated patients of intensive care unit acquired weakness(ICU-AW)with spleen qi defi-ciency syndrome.Methods Seventy-two patients eligible for mechanical ventilation ICU-AW and spleen qi deficiency were selected and randomly divided into routine ICU basic treatment and nursing combined with nasal feeding or oral administration of normal saline 3 times a day,50 ml per time as control group,and routine ICU basic treatment and nursing combined with BYD 3 times a day,50 ml per time as treatment group,with 36 cases in each group.The treatment cycle was 7 days.Traditional Chinese medicine(TCM)syndrome score,Medical Research Council(MRC)score,diaphragm mobility,diaphragm thickness at the end of inspiration and expiration,diaphragm thickness rate,time to successfully remove the tracheal tube,superoxide dismutase(SOD)and malondialdehyde(MDA)levels of patients were measured before and after treatment,and the efficacy of TCM syndrome was evaluated.Results The total effective rate regarding TCM syndrome was 88.89％in the treatment group,which was higher than 66.67％in the control group(P=0.033).After treatment,the main symptom score,secondary symptom score and total score of TCM syndrome,diaphragm mobility and MDA level significantly decreased in both groups,while MRC score,dia-phragm thickness rate and SOD level increased(P＜0.01),with more improvement in the treatment group than in the control group(P＜0.05 or P＜0.01).The number of successful tracheal intubation removal within 7 days after treat-ment in the treatment group(28/36 cases,77.78％)was higher than that in the control group(19/36 cases,52.78％).Conclusion Basic treatment combined with oral administration of BYD can improve the MRC score,general condition,diaphragm contraction,and antioxidant capacity of patients with mechanical ventilation in ICU-AW with spleen qi deficiency,thereby improving the success rate of extubation with sound safety.
intensive care unit acquired weaknessspleen qi deficiencyBuzhong Yiqi Decoction(补中益气汤)Medical Research Council-scorediaphragm excursionserum oxidation levels
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